Τίτλος:
STAT3-Ser/Hes3 Signaling: A New Molecular Component of the
Neuroendocrine System?
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
The endocrine system involves communication among different tissues in
distinct organs, including the pancreas and components of the
Hypothalamic-Pituitary-Adrenal Axis. The molecular mechanisms underlying
these complex interactions are a subject of intense study as they may
hold clues for the progression and treatment of a variety of metabolic
and degenerative diseases. A plethora of signaling pathways, activated
by hormones and other endocrine factors have been implicated in this
communication. Recent advances in the stem cell field introduce a new
level of complexity: adult progenitor cells appear to utilize distinct
signaling pathways than the more mature cells in the tissue they
co-reside. It is therefore important to elucidate the signal
transduction requirements of adult progenitor cells in addition to those
of mature cells. Recent evidence suggests that a common non-canonical
signaling pathway regulates adult progenitors in several different
tissues, rendering it as a potentially valuable starting point to
explore their biology. The STAT3-Ser/Hes3 Signaling Axis was first
identified as a major regulator of neural stem cells and, subsequently,
cancer stem cells. In the endocrine/neuroendocrine system, this pathway
operates on several levels, regulating other types of plastic cells: (a)
it regulates pancreatic islet cell function and insulin release; (b)
insulin in turn activates the pathway in broadly distributed neural
progenitors and possibly also hypothalamic tanycytes, cells with
important roles in the control of the adrenal gland; (c) adrenal
progenitors themselves operate this pathway. The STAT3-Ser/Hes3
Signaling Axis therefore deserves additional research in the context of
endocrinology.
Συγγραφείς:
Nikolakopoulou, P.
Poser, S. W.
Masjkur, J.
de Celis, M.
Fernandez Rubin
Toutouna, L.
Andoniadou, C. L.
McKay, R. D.
and Chrousos, G.
Ehrhart-Bornstein, M.
Bornstein, S. R. and
Androutsellis-Theotokis, A.
Περιοδικό:
Hormone and Metabolic Research
Εκδότης:
Georg Thieme Verlag KG
Λέξεις-κλειδιά:
STAT3; Hes3; stem cells
DOI:
10.1055/s-0041-111699
