Περίληψη:
BACKGROUND
High normal blood pressure (BP; 130-139/85-89 mm Hg) is related with
increased cardiovascular (CV) risk compared to normal BP (120-129/80-84
mm Hg) or/and optimal BP (<120/80 mm Hg). Low apelin plasma levels have
been associated with arterial hypertension and atherosclerosis, while
high visfatin plasma levels may promote vascular inflammation and
atherosclerotic plaque destabilization and have been evaluated as a
marker for identifying stages of essential hypertension. We sought to
compare the apelin and visfatin plasma levels between subjects with high
normal BP and subjects with normal or optimal BP matched for age,
gender, smoking, and body mass index (BMI).
METHODS
Twenty-five subjects with high normal BP (office BP 136 +/- 3/88 +/- 2
mm Hg, age 57 +/- 4 years, 76% males, 32% smokers, BMI 24.0 +/- 1.7
kg/m(2)) and 35 subjects with normal or optimal BP (office BP 118 +/-
2/78 +/- 2 mm Hg, age 55 +/- 7 years, 63% males, 29% smokers, BMI 23.2
+/- 1.4 kg/m(2)) were studied. The apelin and visfatin plasma levels
were determined with the enzyme-linked immunosorbent assay.
RESULTS
Compared to normal or optimal BP subjects, apelin levels were
significantly lower (205 +/- 108 vs. 325 +/- 152 pg/ml, P < 0.001) and
visfatin levels significantly higher (11.0 +/- 2.0 vs. 7.2 +/- 0.9
ng/ml, P = 0.002) in high normal BP subjects. No significant differences
were found between the 2 groups (P = NS) regarding the basic clinical
characteristics, the glycemic/lipid profile, and the renal function
parameters.
CONCLUSIONS
The emerging, from the present study, data raise the hypothesis that
lower apelin and higher visfatin plasma levels in high normal BP
subjects compared to normal or optimal BP individuals could partially
explain the higher CV risk of the high normal BP group.
Συγγραφείς:
Liakos, Charalampos I.
Sanidas, Elias A.
Perrea, Despoina N. and
Grassos, Charalampos A.
Chantziara, Vasiliki
Viniou, Nora-Athina
and Barbetseas, John D.
Papadopoulos, Dimitrios P.
