Τίτλος:
Epidemiological characteristics, management and early outcomes of acute
coronary syndromes in Greece: The PHAETHON study
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Introduction: In view of recent therapeutic breakthroughs in acute
coronary syndromes (ACS) and essential demographic and socioeconomic
changes in Greece, we conducted the prospective, multi-center,
nationwide PHAETHON study (An Epidemiological Cohort Study of Acute
Coronary Syndromes in the Greek Population) that aimed to recruit a
representative cohort of ACS patients and examine current management
practices and patient prognosis.
Methods: The PHAETHON study was conducted from May 2012 to February
2014. We enrolled 800 consecutive ACS patients from 37 hospitals with a
proportional representation of all types of hospitals and geographical
areas. Patients were followed for a median period of 189 days. Outcome
was assessed with a composite endpoint of death, myocardial infarction,
stroke, urgent revascularization and urgent hospitalization for
cardiovascular causes.
Results: The mean age of patients was 62.7 years (78% males). The
majority of patients (n=411, 51%) presented with ST-elevation
myocardial infarction (STEMI), whereas 389 patients presented with
NSTEMI (n=303, 38%) or UA (n=86, 11%). Overall, 58.8% of the patients
had hypertension, 26.5% were diabetic, 52.5% had dyslipidemia, 71.1%
had a smoking history (current or past), 25.8% had a family history of
coronary artery disease (CAD) and 24.1% had a prior history of CAD. In
STEMI patients, 44.5% of patients were treated with thrombolysis,
38.9% underwent a coronary angiogram (34.1% were treated with primary
percutaneous coronary intervention) and 16.5% did not receive urgent
treatment. The pain-to-door time was 169 minutes. During
hospitalization, 301 (38%) patients presented one or more
complications, and 13 died (1.6%). During follow-up, 99 (12.6%)
patients experienced the composite endpoint, and 21 died (2.7%).
Conclusions: The PHAETHON study provided valuable insights into the
epidemiology, management and outcome of ACS patients in Greece.
Management of ACS resembles the management observed in other European
countries. However, several issues still to be addressed by public
authorities for the timely and proper management of ACS. (C) 2016
Hellenic Cardiological Society. Publishing services by Elsevier B. V.
Συγγραφείς:
Andrikopoulos, G.
Terentes-Printzios, D.
Tzeis, S. and
Vlachopoulos, C.
Varounis, C.
Nikas, N.
Lekakis, J. and
Stakos, D.
Lymperi, S.
Symeonidis, D.
Chrissos, D. and
Kyrpizidis, C.
Alexopoulos, D.
Zombolos, S.
Foussas, S. and
Kranidis, A.
Oikonomou, K.
Vasilikos, V.
Andronikos, P. and
Dermitzakis, A.
Richter, D.
Fragakis, N.
Styliadis, I. and
Mavridis, S.
Stefanadis, C.
Vardas, P.
Περιοδικό:
Ελληνική καρδιολογική επιθεώρηση
Εκδότης:
HELLENIC CARDIOLOGICAL SOC
Λέξεις-κλειδιά:
Acute coronary syndromes; Myocardial infarction; Epidemiology; Prognosis
DOI:
10.1016/j.hjc.2016.06.003
