Τίτλος:
Cord blood leptin levels in relation to child growth trajectories
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Objective. Leptin represents a potential modulator of developmental
programming of childhood obesity. We investigated the association of
cord blood leptin with growth trajectories from birth to early
childhood.
Materials/methods. We used data from the prospective mother child cohort
“Rhea”, Crete, Greece. Cord blood samples from 642 neonates were
collected. 578 (90%) children had complete follow up data from birth to
4 years. We measured child weight, height, waist circumference, skinfold
thicknesses, blood pressure, and serum lipids, leptin, adiponectin and
C-reactive protein in early childhood (median 4.2 years). We estimated
growth trajectories from 3 months up to 4 years using random-effects
linear-spline models. Multivariable logistic and linear regression
models were used adjusting for confounders.
Results. Mean cord blood leptin levels were 7.3 ng/mL (standard
deviation: 6.3). Children with high cord blood leptin (>90th percentile)
exhibited lower weight, height and body mass index from 6 months to
early childhood. Each SD increase in cord blood leptin was associated
with lower weight at the age of 4 by 242 g (95% CI: -416, -69). In a
stratified analysis, the reverse association was observed in children
born small for gestational age (p for interaction = 0.001), and in those
exhibiting rapid infant growth during the first 3 months of life (p for
interaction = 0.002). Cord blood leptin levels were not associated with
cardiometabolic risk factors at 4 years.
Conclusions. Long term programming effects of in utero exposure to
leptin extends beyond infancy into early childhood. Further studies are
needed to explore potential effect modification by intrauterine and
early infancy growth patterns. (C) 2016 Elsevier Inc. All rights
reserved.
Συγγραφείς:
Karakosta, Polyxeni
Roumeliotaki, Theano
Chalkiadaki, Georgia
and Sarri, Katerina
Vassilaki, Maria
Venihaki, Maria and
Malliaraki, Niki
Kampa, Marilena
Castanas, Elias
Kogevinas,
Manolis
Mantzoros, Christos
Chatzi, Leda
Περιοδικό:
Metabolism: Clinical and Experimental
Εκδότης:
W B SAUNDERS CO-ELSEVIER INC
Λέξεις-κλειδιά:
Leptin; Cord blood; Birth cohort; Growth; Childhood
DOI:
10.1016/j.metabol.2016.03.003
