Περίληψη:
Objective: The objective of this study is to test if chorionic villus
sampling (CVS) is associated with fetal growth impairment, after
controlling for maternal and fetal factors.Study design: Case-control
study of singleton fetuses whose mothers had undergone CVS (N=442) and
2969 controls. The primary outcomes were the prevalence of birthweight
<10th centile and birthweight <3rd centile; the prevalence of
preeclampsia was the secondary outcome. Tested predictors in logistic
regression analysis included CVS, free beta-hCG MoMs, PAPP-A MoMs,
first-trimester mean uterine artery pulsatility index (PI) z-scores,
maternal height, BMI, age, and smoking.Results: The proportion of
newborns with birthweight <10th centile (7.9 versus 6.2%), and <3rd
centile (1.6 versus 1.1%) did not differ between the two groups.
Maternal age, smoking during pregnancy, PAPP-A MoMs, and mean
first-trimester uterine PI z-score were significant predictors for these
outcomes. Although the prevalence of preeclampsia was higher in the CVS
group (3.2 versus 1.3%, OR 2.62, 95% CI 1.41-4.89), the association
was abolished in the regression analysis, in which maternal body mass
index, free b-hCG levels, and mean first-trimester uterine PI z-score
were the only significant predictors.Conclusions: CVS is not associated
with fetal growth impairment, possibly because the resulting mechanical
disruption is compensated by the developing placenta, without
significantly impairing its function.
Συγγραφείς:
Sotiriadis, Alexandros
Eleftheriades, Makarios
Chatzinikolaou,
Fotios
Chatzistamatiou, Kimon
Assimakopoulos, Efstratios and
Chasiakos, Demetrios
