Περίληψη:
The associations of body mass index (BMI) and other anthropometric
measurements with lung cancer were examined in 348,108 participants in
the European Investigation Into Cancer and Nutrition (EPIC) between 1992
and 2010. The study population included 2,400 case patients with
incident lung cancer, and the average length of follow-up was 11 years.
Hazard ratios were calculated using Cox proportional hazard models in
which we modeled smoking variables with cubic splines. Overall, there
was a significant inverse association between BMI (weight (kg)/height
(m)(2)) and the risk of lung cancer after adjustment for smoking and
other confounders (for BMI of 30.0-34.9 versus 18.5-25.0, hazard ratio =
0.72, 95% confidence interval: 0.62, 0.84). The strength of the
association declined with increasing follow-up time. Conversely, after
adjustment for BMI, waist circumference and waist-to-height ratio were
significantly positively associated with lung cancer risk (for the
highest category of waist circumference vs. the lowest, hazard ratio =
1.25, 95% confidence interval: 1.05, 1.50). Given the decline of the
inverse association between BMI and lung cancer over time, the
association is likely at least partly due to weight loss resulting from
preclinical lung cancer that was present at baseline. Residual
confounding by smoking could also have influenced our findings.
Συγγραφείς:
Dewi, Nikmah Utami
Boshuizen, Hendriek C.
Johansson, Mattias and
Vineis, Paolo
Kampman, Ellen
Steffen, Annika
Tjonneland,
Anne
Halkjaer, Jytte
Overvad, Kim
Severi, Gianluca and
Fagherazzi, Guy
Boutron-Ruault, Marie-Christine
Kaaks, Rudolf
and Li, Kuanrong
Boeing, Heiner
Trichopoulou, Antonia
Bamia,
Christina
Klinaki, Eleni
Tumino, Rosario
Palli, Domenico and
Mattiello, Amalia
Tagliabue, Giovanna
Peeters, Petra H. and
Vermeulen, Roel
Weiderpass, Elisabete
Gram, Inger Torhild and
Maria Huerta, Jose
Agudo, Antonio
Sanchez, Maria-Jose and
Ardanaz, Eva
Dorronsoro, Miren
Ramon Quiros, Jose
Sonestedt,
Emily
Johansson, Mikael
Grankvist, Kjell
Key, Tim
Khaw,
Kay-Tee
Wareham, Nick
Cross, Amanda J.
Norat, Teresa and
Riboli, Elio
Fanidi, Anouar
Muller, David
Bueno-de-Mesquita,
H. Bas
