Τίτλος:
Female gender is independently associated with increased carotid
temperatures in patients with coronary artery disease
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: Limited are the data regarding the sex differences in
functional carotid artery characteristics. Microwave Radiometry (MWR) is
a new noninvasive method, which measures in vivo instantly the internal
temperatures of tissues, reflecting inflammation. The aim of the present
study was to investigate whether in patients with coronary artery
disease (CAD), gender related differences apply in carotid plaque
functional characteristics, as assessed by MWR.
Methods: Consecutive patients with significant CAD were included in the
study. All patients underwent evaluation of both carotid arteries by 1)
ultrasound and 2) MWR. During ultrasound common carotid IMT and plaque
thickness were assessed according to Mannheim consensus. During MWR
measurements, temperature difference (Delta T) was assigned as maximal
temperature along the carotid artery minus minimum. Delta T >= 0.90
degrees C was assigned as high Delta T.
Results: In total 364 patients with significant CAD were included in the
study. Of these 54 were female and 310 were male. Max plaque thickness
and ccIMT were similar between males and females (2.38 +/- 1.16 vs. 2.46
+/- 1.12 mm, p = 0.63 and 0.944 +/- 0.172 vs. 0.942 +/- 0.169 mm, p =
0.96). Carotid arteries of females showed higher Delta T values (1.16
+/- 0.48 vs 0.87 +/- 0.45 degrees C, p < 0.001). Interestingly, females
had more commonly high Delta T values bilaterally (35.2% vs 15.5%, p =
0.001). In multivariate analysis, female sex was independently
associated with bilateral high Delta T, when adjusted to potential
covariates (OR = 2.78, 95% CI = 1.42-5.45, p = 0.003).
Conclusions: In patients with CAD, sex specific differences apply in
functional but not in structural carotid artery characteristics. Whether
this discrepancy has prognostic significance, remains to be clarified in
future studies. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
Συγγραφείς:
Benetos, Georgios
Toutouzas, Konstantinos
Matsoukis, Ioannis and
Drakopoulou, Maria
Mitropoulou, Fotini
Koutagiar, Iosif and
Nikolaou, Charalampia
Stathogiannis, Konstantinos
Siores, Elias
and Tousoulis, Dimitris
Περιοδικό:
International Journal of Cardiology
Εκδότης:
Elsevier Ireland Ltd
Λέξεις-κλειδιά:
Carotid artery; Gender differences; Inflammation; Microwave radiometry
DOI:
10.1016/j.ijcard.2016.06.006
