Περίληψη:
Iron overload in patients with thalassemia major (TM) affects glucose
regulation and is mediated by several mechanisms. The pathogenesis of
glycaemic abnormalities in TM is complex and multifactorial. It has been
predominantly attributed to a combination of reduced insulin secretory
capacity and insulin resistance. The exact mechanisms responsible for
progression from norm glycaemia to overt diabetes in these patients are
still poorly understood but are attributed mainly to insulin deficiency
resulting from the toxic effects of iron deposited in the pancreas and
insulin resistance. A group of endocrinologists, haematologists and
paediatricians, members of the International Network of Clinicians for
Endocrinopathies in Thalassemia and Adolescence Medicine (ICET-A)
convened to formulate recommendations for the diagnosis and management
of abnormalities of glucose homeostasis in thalassemia major patients on
the basis of available evidence from clinical and laboratory data and
consensus practice. The results of their work and discussions are
described in this article.
Συγγραφείς:
De Sanctis, Vincenzo
Soliman, Ashraf T.
Elsedfy, Heba and
Yaarubi, Saif A. L.
Skordis, Nicos
Khater, Doaa
El Kholy,
Mohamed
Stoeva, Iva
Fiscina, Bernadette
Angastiniotis,
Michael
Daar, Shahina
Kattamis, Christos
