Τίτλος:
Mutations of Two Major Coagulation Factors Are Not Associated with Male
Infertility
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: Thrombophilia-related mutations, such as coagulation factor
V Leiden and factor II (G20210A), have been associated with female
infertility due to spontaneous abortions during pregnancy. The possible
role of mutations of these two factors in male infertility has not been
studied to date. Materials and Methods: A total of 208 unrelated Greek
men were investigated, including 108 infertile men with idiopathic
oligozoospermia, azoospermia, and oligozoospermia of various etiologies,
as well as 100 fertile male controls. DNA extracted from participants'
sperm or blood was analyzed for factor V Leiden and factor II G20210A
mutations. Results: There were no significant differences in factor V
and factor II genotypes between infertile men and normal controls.
Conclusion: An association of the two common thrombophilia-related
mutations with male infertility was not observed in this preliminary
study.
Συγγραφείς:
Yapijakis, Christos
Pachis, Nikos
Avgoustidis, Dimitris and
Adamopoulou, Mary
Serefoglou, Zoe
Περιοδικό:
In vivo (Athens, Greece)
Εκδότης:
INT INST ANTICANCER RESEARCH
Λέξεις-κλειδιά:
Male infertility; coagulation factors; mutations
DOI:
10.21873/invivo.11015
