Περίληψη:
Objective There is uncertainty about the direction and magnitude of the
associations between parity, breastfeeding and the risk of coronary
heart disease (CHD). We examined the separate and combined associations
of parity and breastfeeding practices with the incidence of CHD later in
life among women in a large, pan-European cohort study.
Methods Data were used from European Prospective Investigation into
Cancer and Nutrition (EPIC)-CVD, a case-cohort study nested within the
EPIC prospective study of 520,000 participants from 10 countries.
Information on reproductive history was available for 14,917 women,
including 5138 incident cases of CHD. Using Prentice-weighted Cox
regression separately for each country followed by a random-effects
meta-analysis, we calculated hazard ratios (HRs) and 95% confidence
intervals (CIs) for CHD, after adjustment for age, study centre and
several socioeconomic and biological risk factors.
Results Compared with nulliparous women, the adjusted HR was 1.19 (95%
CI: 1.01-1.41) among parous women; HRs were higher among women with more
children (e.g., adjusted HR: 1.95 (95% CI: 1.19-3.20) for women with
five or more children). Compared with women who did not breastfeed, the
adjusted HR was 0.71 (95% CI: 0.52-0.98) among women who breastfed. For
childbearing women who never breastfed, the adjusted HR was 1.58 (95%
CI: 1.09-2.30) compared with nulliparous women, whereas for childbearing
women who breastfed, the adjusted HR was 1.19 (95% CI: 0.99-1.43).
Conclusion Having more children was associated with a higher risk of CHD
later in life, whereas breastfeeding was associated with a lower CHD
risk. Women who both had children and breastfed did have a
non-significantly higher risk of CHD.
Συγγραφείς:
Peters, Sanne A. E.
van der Schouw, Yvonne T.
Wood, Angela M.
and Sweeting, Michael J.
Moons, Karel G. M.
Weiderpass,
Elisabete
Arriola, Larraitz
Benetou, Vassiliki
Boeing,
Heiner
Bonnet, Fabrice
Butt, Salma T.
Clavel-Chapelon,
Francoise
Drake, Isabel
Gavrila, Diana
Key, Timothy J. and
Klinaki, Eleni
Krogh, Vittorio
Kuehn, Tilman
Lassale,
Camille
Masala, Giovanna
Matullo, Giuseppe
Merritt, Melissa
and Molina-Portillo, Elena
Moreno-Iribas, Conchi
Nost, Therese
H.
Olsen, Anja
Onland-Moret, N. Charlotte
Overvad, Kim and
Panico, Salvatore
Redondo, M. Luisa
Tjonneland, Anne and
Trichopoulou, Antonia
Tumino, Rosario
Turzanski-Fortner, Renee
and Tzoulaki, Ioanna
Wennberg, Patrik
Winkvist, Anna and
Thompson, Simon G.
Di Angelantonio, Emanuele
Riboli, Elio and
Wareham, Nicholas J.
Danesh, John
Butterworth, Adam S.
