Τίτλος:
Statins in Stable Angina Pectoris
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: Stable angina is a debilitating and progressive disease
caused by narrowing of the coronary arteries, which in turn affects
cardiac perfusion. Statins have a well-established role, modifying
symptoms and progression of the disease not only through lipid lowering,
but also through pleiotropic effects.
Objective: We sought to evaluate the effect of statins in stable angina
pectoris
Method: We performed a systematic review of the literature searching
MEDLINE via Pubmed for all studies which examine the possible effects of
statins in stable angina pectoris.
Results: Statins have demonstrated favourable modification of both
biochemical markers (oxidative stress, inflammatory and coagulation
markers/factors) and clinical symptoms (anginal and ischemic) of the
disease. These effects have been demonstrated in vitro, ex vivo and in
vivo in animals and humans, independently of the lipid lowering effects.
Conclusion: With an excellent safety profile and evidence of efficacy in
managing patients with stable angina, statins appear an essential part
of the therapeutic armoury against atherosclerotic disease.
Συγγραφείς:
Ioannou, Adam
Papageorgiou, Nikolaos
McCaughan, Vincent and
Charakida, Marietta
Bertsias, Dimitris
Zacharia, Fay
Siasos,
Gerasimos
Latsios, George
Papaioannou, Spyridon
Oikonomou,
Evangelos
Tousoulis, Dimitris
Περιοδικό:
Current Pharmaceutical Design
Εκδότης:
BENTHAM SCIENCE PUBL LTD
Λέξεις-κλειδιά:
Stable angina; statins; atherosclerosis; ischaemia; pleiotropic effects;
coronary arteries
DOI:
10.2174/1381612823666170828132303
