Περίληψη:
Mesenchymal stem cells (MSCs) are an attractive source for regenerative
medicine because they are easily accessible through minimally invasive
methods and have the potential to enhance liver regeneration (LG) and
improve liver function, following partial hepatectomy (PH) and acute or
chronic liver injury. A systematic review of the literature was
conducted for articles published up to September 1st, 2016, using the
MEDLINE database. The keywords that were used in various combinations
were as follows: “Mesenchymal stem cells”, “transplantation”,
“stem cells”, “adipose tissue derived stem cells”, “bone
marrow-derived stem cells”, “partial hepatectomy”, “acute liver
failure”, “chronic liver failure”, “liver fibrosis”, “liver
cirrhosis”, “rats”, “mice”, and “liver regeneration”. All
introduced keywords were searched for separately in MeSH Database to
control relevance and terminological accuracy and validity. A total of
41 articles were identified for potential inclusion and reviewed in
detail. After a strict selection process, a total of 28 articles were
excluded, leaving 13 articles to form the basis of this systematic
review. MSCs transplantation promoted LG and improved liver function.
Furthermore, MSCs had the ability to differentiate in hepatocyte-like
cells, increase survival, and protect hepatocytes by paracrine
mechanisms. MSCs transplantation may provide beneficial effects in the
process of LG after PH and acute or chronic liver injury. They may
represent a new therapeutic option to treat posthepatectomy acute liver
failure.
Συγγραφείς:
Papanikolaou, Ioannis G.
Katselis, Charalambos
Apostolou,
Konstantinos
Feretis, Themistoklis
Lymperi, Maria and
Konstadoulakis, Manousos M.
Papalois, Apostolos E.
Zografos,
George C.
