Ερευνητικό υλικό ΕΚΠΑ

Coronary Artery Atherosclerosis in Hypertensive Patients: The Role of
Fibrinogen Genetic Variability

Introduction and objectives: We examined whether the rs180070 and
rs2070011 polymorphisms of the fibrinogen gene could affect the risk of
coronary artery disease in hypertensive patients by modifying the
inflammatory process and coagulation.
Methods: A total of 744 participants underwent coronary angiography due
to symptoms of stable angina, while hypertension was present in 332
patients.
Results: The presence of the A allele (rs180070) was associated with
significantly high levels of fibrinogen in hypertensive patients (P
=.05). On multivariate analysis, A homozygosity (rs180070) (b = 0.257
+/- 18.6; P <.001), but not hypertension status (beta= 0.05 +/- 11.9; P
=.29) was an independent predictor of fibrinogen levels. In hypertensive
patients, higher fibrinogen levels > 443 mg/dL (odds ratio = 3.50; 95%
confidence interval, 1.14-10.90; P =.029), but not A homozygosity (odds
ratio = 3.00; 95% confidence interval, 0.78-11.90; P =.110) were
independent predictors of the presence of coronary artery disease.
Moreover, interleukin-6 levels were higher in A homozygotes for the
rs180070 polymorphism compared with all other genotypes (P =.046).
Indeed, this genotype was the only adjusted independent predictor of
interleukin- 6 levels (beta = 0.151 +/- 0.642; P =.032). It was also
associated with higher D-dimer levels in hypertension compared with G
allele carriers (P =.048).
Conclusions: The presence of A homozygosity (rs180070) is associated
with increased levels of inflammatory mediators and a higher incidence
of angiographic coronary artery disease. Importantly, fibrinogen is an
independent predictor of the angiographic presence of coronary artery
disease in hypertensive patients.
Full English text available from: www.revespcardiol.org/en (C) 2016
Sociedad Espanola de Cardiologia. Published by Elsevier Espana, S.L.U.
All rights reserved.

2017

Papageorgiou, Nikolaos
Briasoulis, Alexandros
Hatzis, Georgios
and Androulakis, Emmanuel
Kozanitou, Maria
Miliou, Antigoni and
Charakida, Marietta
Zacharia, Effimia
Papaioannou, Spyridon and
Paroutoglou, Ioannis
Siasos, Gerasimos
Pallantza, Zoi and
Tousoulis, Dimitris

Revista Espanola De Cardiologia

EDICIONES DOYMA S A

70

1

34-41

Coronary artery disease; Fibrinogen; Hypertension; Polymorphisms

https://doi.org/10.1016/j.recesp.2016.05.027

10.1016/j.recesp.2016.05.027

https://pergamos.lib.uoa.gr/uoa/dl/object/3173284