Περίληψη:
Background Common autoimmune diseases tend to coexist in the same
patients. Few studies have examined the possible association between
autoimmune thyroiditis and psoriasis or psoriatic arthritis (PsA), with
inconsistent results.
Objective To investigate the prevalence of autoimmune thyroiditis in
psoriatic patients with or without PsA, living in an iodine-sufficient
area.
Methods We studied prospectively, 114 psoriatic patients with disease
duration of 5-38 years, 30 of them with PsA, and 286 age-and body mass
index (BMI)-matched subjects without psoriasis or known thyroid disease
or autoimmune disease. A detailed medical history was obtained from all
participants and clinical examination and laboratory evaluation was
performed. Psoriasis severity was assessed with Psoriasis Area and
Severity Index (PASI). Autoimmune thyroiditis was defined by the
presence of positive autoantibodies to thyroid peroxidase and/or
thyroglobulin.
Results There was no difference in the prevalence of autoimmune
thyroiditis between psoriatic patients and controls (20.2% vs. 19.6%).
The prevalence of autoimmune thyroiditis in male and female psoriatic
patients was similar (9.6% and 10.5% respectively), in contrast to the
increased, as expected, prevalence in female vs. male controls (14.7%
vs. 4.9%, P < 0.01). Detected cases with hypothyroidism due to
autoimmune thyroiditis were similar in psoriatic patients and controls
(7.9% and 7.0% respectively). Autoimmune thyroiditis in psoriatic
patients was not related with age of psoriasis onset, psoriasis
duration, PASI score, PsA and obesity.
Conclusion These data support that psoriatic patients with or without
PsA do not have an increased risk for autoimmune thyroiditis.
Συγγραφείς:
Vassilatou, E.
Papadavid, E.
Papastamatakis, P.
Alexakos, D.
and Koumaki, D.
Katsimbri, P.
Hadjidakis, D.
Dimitriadis, G.
and Rigopoulos, D.
