Τίτλος:
Patterns of drug resistance among patients with tuberculous pleural
effusion in Greece
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
SETTING: Data on the relationship between pleural tuberculosis (TB) and
anti-tuberculosis drug resistance are scarce.
OBJECTIVE: To determine the patterns of drug resistance among pleural
Mycobacterium tuberculosis isolates in Greece and the incidence of
tuberculous pleural effusion (TPE) among patients with
multidrug-resistant (MDR) or extensively drug-resistant (XDR) pulmonary
TB.
DESIGN: Drug susceptibility testing (DST) results recorded in the
database of the National Reference Centre for Tuberculosis in Athens,
Greece, over a 9-year period (2003-2011) were reviewed. Chest X-rays
from hospitalised patients with pulmonary MDR/XDR-TB during the same
period were also reviewed for the presence of TPE.
RESULTS: Resistance to at least one first-line drug was observed in 11%
of the cases (MDR-TB 3%, XDR-TB 1%), while 29% of the patients with
pulmonary MDR/XDR-TB presented with TPE during the course of their
disease, the majority ipsilateral to the lung lesions, which responded
to guided anti-tuberculosis treatment.
CONCLUSION: The prevalence of drug resistance among pleural M.
tuberculosis isolates in Greece highlights the importance of DST prior
to treatment selection in TPE patients. In our study population, TPE
that developed in one third of the patients with pulmonary MDR/XDR-TB
usually resolved with DST guided anti-tuberculosis treatment.
Συγγραφείς:
Anastasakos, V.
Skouras, V.
Moschos, C.
Tsikrika, S. and
Karabela, S.
Marinou, L.
Vogiatzakis, E.
Konstantinou, K.
and Papavasiliou, A.
Kalomenidis, I.
Περιοδικό:
The International Journal of Tuberculosis and Lung Disease
Εκδότης:
INT UNION AGAINST TUBERCULOSIS LUNG DISEASE (I U A T L D)
Λέξεις-κλειδιά:
tuberculous pleuritis; tuberculous pleurisy; isoniazid resistance;
pleural biopsy
DOI:
10.5588/ijtld.16.0155
