Περίληψη:
Insulin-like growth factor (IGF)-I has cancer promoting activities.
However, the hypothesis that circulating IGF-I concentration is related
to risk of lymphoma overall or its subtypes has not been examined
prospectively. IGF-I concentration was measured in pre-diagnostic plasma
samples from a nested case-control study of 1,072 cases of lymphoid
malignancies and 1,072 individually matched controls from the European
Prospective Investigation into Cancer and Nutrition. Odds ratios (ORs)
and confidence intervals (CIs) for lymphoma were calculated using
conditional logistic regression. IGF-I concentration was not associated
with overall lymphoma risk (multivariable-adjusted OR for highest versus
lowest third = 0.77 [95% CI = 0.57-1.03], p(trend) = 0.06). There was
no statistical evidence of heterogeneity in this association with IGF-I
by sex, age at blood collection, time between blood collection and
diagnosis, age at diagnosis, or body mass index (pheterogeneity for all
>= 0.05). There were no associations between IGF-I concentration and
risk for specific BCL subtypes, T-cell lymphoma or Hodgkin lymphoma,
although number of cases were small. In this European population, IGF-I
concentration was not associated with risk of overall lymphoma. This
study provides the first prospective evidence on circulating IGF-I
concentrations and risk of lymphoma. Further
What’s new?
Insulin-like growth factor I does not appear to influence lymphoma risk,
according to new results. IGF-I can promote some cancers, but there
hasn’t been a prospective epidemiological study examining the link
between IGF-I concentration and lymphoma risk. To uncover a link, these
authors arranged a NESTED case-control study with participants from the
European Prospective Investigation into Cancer and Nutrition (EPIC).
They tested for IGF-I in pre-diagnosis samples and found no association
between the factor and overall lymphoma risk, nor with any subtype,
although the number of cases was small for each subtype, and further
studies are necessary.
Συγγραφείς:
Perez-Cornago, Aurora
Appleby, Paul N.
Tipper, Sarah
Key,
Timothy J.
Allen, Naomi E.
Nieters, Alexandra
Vermeulen,
Roel
Roulland, Sandrine
Casabonne, Delphine
Kaaks, Rudolf
and Fortner, Renee T.
Boeing, Heiner
Trichopoulou, Antonia and
La Vecchia, Carlo
Klinaki, Eleni
Hansen, Louise
Tjonneland,
Anne
Bonnet, Fabrice
Fagherazzi, Guy
Boutron-Ruault,
Marie-Christine
Pala, Valeria
Masala, Giovanna
Sacerdote,
Carlotta
Peeters, Petra H.
Bueno-de-Mesquita, H. B(as) and
Weiderpass, Elisabete
Dorronsoro, Miren
Quiros, J. Ramon and
Barricarte, Aurelio
Gavrila, Diana
Agudo, Antonio
Borgquist,
Signe
Rosendahl, Ann H.
Melin, Beatrice
Wareham, Nick and
Khaw, Kay-Tee
Gunter, Marc
Riboli, Elio
Vineis, Paolo and
Travis, Ruth C.
