Περίληψη:
Background: Emerging evidence from cohort studies indicates that
adiposity is associated with greater incidence of head and neck cancer.
However, most studies have used self-reported anthropometry which is
prone to error.
Methods: Among 363,094 participants in the European Prospective
Investigation into Cancer and Nutrition study (EPIC) with measured
anthropometry, there were 837 incident cases of head and neck cancer.
Head and neck cancer risk was examined in relation to body mass index
(BMI) [lean: <22.5 kg/m(2), normal weight (reference): 22.5-24.9
kg/m(2), overweight 25-29.9 kg/m(2), obese: >= 30 kg/m(2)], waist
circumference (WC), hip circumference (HC), and waist-to-hip ratio (WHR)
using Cox proportional hazards models.
Results: Among men, a BMI <22.5 kg/m(2) was associated with higher head
and neck cancer risk [HR 1.62; 95% confidence interval (CI),
1.23-2.12)]; BMI was not associated with head and neck cancer among
women. WC and WHR were associated with greater risk of head and neck
cancer among women (WC per 5 cm: HR, 1.08; 95% CI, 1.02-1.15; WHR per
0.1 unit: HR, 1.64; 95% CI, 1.38-1.93). After stratification by smoking
status, the association for WHR was present only among smokers
(P-interaction = 0.004). Among men, WC and WHR were associated with head
and neck cancer only upon additional adjustment for BMI (WC per 5 cm: HR
1.16; 95% CI, 1.07-1.26; WHR per 0.1 unit: HR, 1.42; 95% CI,
1.21-1.65).
Conclusions: Central adiposity, particularly among women, may have a
stronger association with head and neck cancer risk than previously
estimated.
Συγγραφείς:
Ward, Heather A.
Wark, Petra A.
Muller, David C.
Steffen,
Annika
Johansson, Mattias
Norat, Teresa
Gunter, Marc J. and
Overvad, Kim
Dahm, Christina C.
Halkjaer, Jytte
Tojonneland,
Anne
Boutron-Ruault, Marie-Christine
Fagherazzi, Guy and
Mesrine, Sylvie
Brennan, Paul
Freisling, Heinz
Li, Kuanrong
and Kaaks, Rudolf
Trichopoulou, Antonia
Lagiou, Pagona and
Panico, Salavatore
Grioni, Sara
Tumino, Rosario
Vineis,
Paolo
Palli, Domenico
Peeters, Petra H. M. and
Bueno-de-Mesquita, H. Bas.
Weiderpass, Elisabete
Agudo, Antonio
and Ramon Quiros, Jose
Larranaga, Nerea
Ardanaz, Eva
Maria
Huerta, Jose
Sanchez, Maria-Jose
Laurell, Goran
Johansson,
Ingegerd
Westin, Ulla
Wallstrom, Peter
Bradbury, Kathryn E.
and Wareham, Nicholas J.
Khaw, Kay-Tee
Pearson, Clare and
Boeing, Heiner
Riboli, Elio
