Περίληψη:
An individual participant data meta-analysis was conducted in the data
of 14 673 Japanese participants without a history of cardiovascular
disease (CVD) to examine the association of the brachial-ankle pulse
wave velocity (baPWV) with the risk of development of CVD. During the
average 6.4-year follow-up period, 687 participants died and 735
developed cardiovascular events. A higher baPWV was significantly
associated with a higher risk of CVD, even after adjustments for
conventional risk factors (P for trend <0.001). When the baPWV values
were classified into quintiles, the multivariable-adjusted hazard ratio
for CVD increased significantly as the baPWV quintile increased. The
hazard ratio in the subjects with baPWV values in quintile 5 versus that
in those with the values in quintile 1 was 3.50 (2.14-5.74; P<0.001).
Every 1 SD increase of the baPWV was associated with a 1.19-fold
(1.10-1.29; P<0.001) increase in the risk of CVD. Moreover, addition of
baPWV to a model incorporating the Framingham risk score significantly
increased the C statistics from 0.8026 to 0.8131 (P<0.001) and also
improved the category-free net reclassification (0.247; P<0.001). The
present meta-analysis clearly established baPWV as an independent
predictor of the risk of development of CVD in Japanese subjects without
preexisting CVD. Thus, measurement of the baPWV could enhance the
efficacy of prediction of the risk of development of CVD over that of
the Framingham risk score, which is based on the traditional
cardiovascular risk factors.
Συγγραφείς:
Ohkuma, Toshiaki
Ninomiya, Toshiharu
Tomiyama, Hirofumi and
Kario, Kazuomi
Hoshide, Satoshi
Kita, Yoshikuni
Inoguchi,
Toyoshi
Maeda, Yasutaka
Kohara, Katsuhiko
Tabara, Yasuharu
and Nakamura, Motoyuki
Ohkubo, Takayoshi
Watada, Hirotaka and
Munakata, Masanori
Ohishi, Mitsuru
Ito, Norihisa
Nakamura,
Michinari
Shoji, Tetsuo
Vlachopoulos, Charalambos
Yamashina,
Akira
Collaborative Grp J-BAVEL Japan
