Περίληψη:
Background. We attempted to validate the performance of a fast
myocardial perfusion imaging (MPI) protocol in diagnostically
challenging patients.
Methods. 78 patients with BLI > 24.9, LVH or three vessels disease
underwent two sequential gated-MPI studies. The first at 15 (Early
Imaging, EI) and the second at 45 (Late Imaging, LI) minutes post (99m)
Tc-injection, at both stress and rest. Counts over heart (H), liver
(Liv) and subdiaphragmatic space (Sub) and image quality, and myocardial
perfusion and function parameters were compared between the two
protocols. Coronary angiography was performed within 2 months from MPI,
and ROC analysis was used to compare the diagnostic accuracy for the
detection of >= 50% diameter luminal stenosis.
Results. Quality was optimal-good in 93% of EI and 98% of LI studies
(P = .12), H/Liv and stress H/Sub ratios were similar, but rest H/Sub
ratio was lower in EI (P = .009). SSS [10 (0 to 46) vs 9 (0 to 36), P
= .006] and SDS [3 (0 to 35) vs 2 (0 to 34), P = .02] were higher in
EI protocol. LVEF, motion and thickening scores did not differ between
the two protocols. A highly significant (P < .001) linear relationship
with clinically negligible mean differences in Bland-Altman analysis was
observed for all perfusion and function-related data. Sensitivity (EI
81%, LI 80%) and specificity (65% for both) did not differ (P = .23)
between the two protocols.
Conclusion. The fast protocol is technically feasible and diagnostically
accurate compared to the established protocol in diagnostically
challenging patients.
Συγγραφείς:
Katsikis, Athanasios
Theodorakos, Athanasios
Kouzoumi, Anna and
Kitziri, Elpida
Georgiou, Evangelos
Koutelou, Maria
