Τίτλος:
Association of matrix gamma-carboxyglutamic acid protein levels with
insulin resistance and Lp(a) in diabetes: A cross-sectional study
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Aims: The risk of cardiovascular disease (CVD) and mortality is
increased in patients with chronic kidney disease (CKD), with a
background role of vascular calcification in the development of CVD also
reported. Studies have demonstrated that high lipoprotein(a) (Lp(a))
levels accelerate the development of atherosclerolsis and are
potentially involved in the vascular calcification. Matrix Gla Protein
(MGP) seems to play an important role in vascular calcification. The aim
of the study was to examine the potential association of MGP
concentrations with Lp(a) and insulin resistance.
Methods: The study involved 100patients divided in four groups: 25 with
both CKD stage 4 and Type2 Diabetes (DM) (Group-A), 25 with CKD4 without
DM (Group-B), 25 non uremic patients with DM (Group-C) and 25 healthy
subjects (Group-D). Serum glucose, Lp(a), MGP, plasma HBA1c and insulin
were measured in all patients. Insulin resistance was estimated by the
homeostasis model assessment equation (HOMA-IR).
Results: A significant positive linear association between MGP and Lp(a)
levels (r = 0.272, p = 0.006) was noted, as well as between MGP and
HOMA-IR levels (r = 0.308, p = 0.002). However, no significant linear
association between Lp(a) and HOMA-IR levels was recorded. A similar
positive association between MGP and insulin levels (r = 0.204, p =
0.042) was also found.
Conclusion: This study concluded that diabetes coexisting with renal
disease leads to extreme vascular calcification expressed by elevated
MGP levels, resulting in higher frequency of cardiovascular disease in
comparison to CKD patients without diabetes. The detected Lp(a) and MGP
association in CKD4 patients may also represent the key to the
complicated mechanism of their coexisting accelerated atherosclerosis
and vascular calcification. (C) 2017 Elsevier B.V. All rights reserved.
Συγγραφείς:
Antonopoulos, Stavros
Mylonopoulou, Maria
Angelidi, Angeliki M.
and Kousoulis, Antonis A.
Tentolouris, Nicholas
Περιοδικό:
Diabetes Research and Clinical Practice
Εκδότης:
Elsevier Ireland Ltd
Λέξεις-κλειδιά:
Matrix gamma-carboxyglutamic acid; protein (MGP); Insulin resistance;
Lipoprotein(a); Diabetes mellitus type 2; Chronic kidney disease
DOI:
10.1016/j.diabres.2017.06.015
