Τίτλος:
Lactate serum concentrations during treatment with nucleos(t)ide
analogues in hepatitis B with or without cirrhosis
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Objective The aim of this study is to evaluate the clinical implications
of lactate concentrations in patients with hepatitis B with or without
cirrhosis during treatment with nucleos(t)ide analogues.
Patients and methods One hundred and seven consecutive patients with
chronic hepatitis B and median age 57(24-85) years were prospectively
included. Lactate concentrations were measured at baseline and at 12,
24, 36, 48, and 60 months following the baseline measurements. Eight
(n=8, 7.5%) patients received lamivudine, 38 (n=38, 35.5%) patients
received tenofovir, 34 (n=34, 31.8%) patients received entecavir, and
27 (n=27, 25.2%) patients received combined therapy.
Results None of the patients developed lactic acidosis during follow-up
[median: 58 (6-155) months]. Overall, no trends of the lactic acid
evolution were observed over time; however, there was a nonsignificant
increasing trend in patients with cirrhosis up to 24 months of
treatment. This increasing trend was significant in female patients with
cirrhosis (P=0.016). The age of the patients, the presence of cirrhosis,
and hepatocellular carcinoma were strongly associated with the survival
of all patients. In the group of cirrhotic patients, the only
independent prognostic factor that was associated with patients’
survival was the Child-Pugh class.
Conclusion None of the patients developed lactic acidosis. There is an
indication of an increasing trend of lactic acid levels up to 24 months
of therapy in female cirrhotic patients. Copyright (C) 2017 Wolters
Kluwer Health, Inc. All rights reserved.
Συγγραφείς:
Triantos, Christos
Kalafateli, Maria
Aggeletopoulou, Ioanna and
Mandellou, Martha
Assimakopoulos, Stelios
Tselekouni, Paraskevi
and Taprantzi, Dimitra
Tsiaoussis, Giorgos
Vourli, Georgia and
Anastassiou, Evangelos D.
Gogos, Charalambos and
Labropoulou-Karatza, Chrisoula
Thomopoulos, Konstantinos
Περιοδικό:
European Journal of Gastroenterology and Hepatology
Εκδότης:
Lippincott, Williams & Wilkins
Λέξεις-κλειδιά:
cirrhosis; hepatitis B virus; lactate acid; nucleos(t)ide analogues
therapy
DOI:
10.1097/MEG.0000000000000924
