Τίτλος:
Cardiovascular Risk Factors Accelerate Progression of Vascular Aging in
the General Population Results From the CRAVE Study (Cardiovascular Risk
Factors Affecting Vascular Age)
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Vascular aging, as assessed by structural and functional arterial
properties, is an independent predictor of cardiovascular risk. We
hypothesized that the number of cardiovascular risk factors determines
the progression of vascular aging. One hundred forty-two subjects (mean
age 51.9 years, 94 men) without established cardiovascular disease were
investigated in 2 examinations over a 2-year period. Subjects were
classified at baseline according to their number of risk factors (from 0
to 2 and more). Subjects had determinations of carotid-femoral pulse
wave velocity, aortic augmentation index, brachial flow-mediated
dilatation, and common carotid intima-media thickness and their annual
absolute changes were calculated. Subjects with more risk factors had a
gradual higher annual progression of pulse wave velocity (0.092 m/s/y
for 0, 0.152 m/s/y for 1, and 0.352 m/s/y for 2 and more; P=0.007).
Patients with both hypertension and dyslipidemia have 4x higher annual
progression rate compared with subjects without these risk factors
(0.398 m/s/y versus 0.102 m/s/y). When only subjects 55 years old and
under were considered, the progression rate of augmentation index was
higher in subjects with more risk factors (1.15%/y versus 1.50%/y
versus 2.99%/y, respectively; P=0.037). No association was found with
the annual change of flow-mediated dilatation or carotid intima-media
thickness. In the general population, increasing number of risk factors
is associated with accelerated deterioration of specific indices of
vascular aging, such as pulse wave velocity and augmentation index; in
contrast, flow-mediated dilatation and carotid intima-media thickness
are insensitive to such changes. Accordingly, the former may be more
useful for gauging vascular aging.
Συγγραφείς:
Terentes-Printzios, Dimitrios
Vlachopoulos, Charalambos and
Xaplanteris, Panagiotis
Ioakeimidis, Nikolaos
Aznaouridis,
Konstantinos
Baou, Katerina
Kardara, Despina
Georgiopoulos,
Georgios
Georgakopoulos, Christos
Tousoulis, Dimitrios
Περιοδικό:
JOURNAL OF HYPERTENSION
Εκδότης:
Lippincott, Williams & Wilkins
Λέξεις-κλειδιά:
aging; atherosclerosis; carotid intima-media thickness; endothelium;
pulse wave analysis; pulse wave velocity; vascular stiffness
DOI:
10.1161/HYPERTENSIONAHA.117.09633
