Τίτλος:
Isolated skeletal muscle recurrence of an originally nodal diffuse large
B cell lymphoma A case report and review of the literature
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Rationale: Diffuse large B cell lymphoma (DLBCL) is a malignancy of the
B cells with extranodal primary involvement being estimated at 30% to
40% of cases. Primary skeletal muscle presentation of DLBCL is
extremely rare, with an estimated incidence of about 0.5% of extranodal
lymphomas, presenting mostly in the lower extremities. The possible
mechanisms of muscle involvement of DLBCL include primary extranodal
disease, extension from adjacent organs (such as lymph nodes) or
disseminated disease.
Patient concerns: We report a case of a 70-year-old woman with an
advanced initially nodal DLBCL, treated with R-CHOP, that presented with
an enlargement of her left thigh and restricted mobility 3 months after
completion of chemotherapy. Imaging studies were performed, which showed
possible infiltration of the muscles of the left thigh, without any
nodal disease present.
Diagnoses: Muscle biopsy documented the recurrence of the lymphoma at
the left thigh.
Interventions: The patient started second-line treatment with
gemcitabine and vinorelbine.
Outcomes: A partial response was achieved after the first cycle.
Lessons: The remarkable element lies in the reappearance of the lymphoma
at the left thigh muscles, with no radiographic or clinical evidence of
involvement of lymph nodes, despite the extensive lymph node disease at
initial presentation. The further management of such recurrences remains
to be clarified, as the odd biological behavior of the malignant cells
dictates a special handling of the disease.
Συγγραφείς:
Spetsieris, Nikolaos
Giannakopoulou, Nefeli
Variami, Eleni and
Zervakis, Konstantinos
Rougala, Niki
Garefalakis, Georgios and
Skarlatou, Vasiliki
Viniou, Nora-Athina
Diamantopoulos,
Panagiotis
Περιοδικό:
MEDICINA-LITHUANIA
Εκδότης:
Lippincott, Williams & Wilkins
Λέξεις-κλειδιά:
extranodal recurrence; lymphoma relapse; lymphoma relapse radiographic
images; lymphoma second-line treatment; muscle infiltration
DOI:
10.1097/MD.0000000000009608
