Περίληψη:
With the aim to dissect the effect of adult height on head and neck
cancer (HNC), we use the Mendelian randomization (MR) approach to test
the association between genetic instruments for height and the risk of
HNC. 599 single nucleotide polymorphisms (SNPs) were identified as
genetic instruments for height, accounting for 16% of the phenotypic
variation. Genetic data concerning HNC cases and controls were obtained
from a genome-wide association study. Summary statistics for genetic
association were used in complementary MR approaches: the weighted
genetic risk score (GRS) and the inverse-variance weighted (IVW).
MR-Egger regression was used for sensitivity analysis and pleiotropy
evaluation. From the GRS analysis, one standard deviation (SD) higher
height (6.9 cm; due to genetic predisposition across 599 SNPs) raised
the risk for HNC (Odds ratio (OR), 1.14; 95% Confidence Interval (95%
CI), 0.99-1.32). The association analyses with potential confounders
revealed that the GRS was associated with tobacco smoking (OR = 0.80,
95% CI (0.69-0.93)). MR-Egger regression did not provide evidence of
overall directional pleiotropy. Our study indicates that height is
potentially associated with HNC risk. However, the reported risk could
be underestimated since, at the genetic level, height emerged to be
inversely associated with smoking.
Συγγραφείς:
Pastorino, Roberta
Puggina, Anna
Carreras-Torres, Robert and
Lagiou, Pagona
Holcatova, Ivana
Richiardi, Lorenzo and
Kjaerheim, Kristina
Agudo, Antonio
Castellsague, Xavier and
Macfarlane, Tatiana V.
Barzan, Luigi
Canova, Cristina and
Thakker, Nalin S.
Conway, David I.
Znaor, Ariana
Healy,
Claire M.
Ahrens, Wolfgang
Zaridze, David and
Szeszenia-Dabrowska, Neonilia
Lissowska, Jolanta
Fabianova,
Eleonora
Mates, Ioan Nicolae
Bencko, Vladimir
Foretova,
Lenka
Janout, Vladimir
Brennan, Paul
Gaborieau, Valerie and
Mckay, James D.
Boccia, Stefania
