The role of transient receptor potential polycystin channels in bone diseases

Επιστημονική δημοσίευση - Άρθρο Περιοδικού uoadl:3180178 21 Αναγνώσεις

Μονάδα:
Ερευνητικό υλικό ΕΚΠΑ
Τίτλος:
The role of transient receptor potential polycystin channels in bone
diseases
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Transient receptor potential (TRP) channels are cation channels which
act as molecular sensors that enable cells to detect and respond to a
plethora of mechanical and environmental cues. TRPs are involved in
various physiological processes, such as mechanosensation, non-inception
and thermosensation, while mutations in genes encoding them can lead to
pathological conditions, called “channelopathies”. The subfamily of
transient receptor potential polycystins (TRPPs), Polycystin 1 (PC1,
TRPP1) and Polycystin 2 (PC2, TRPP2), act as mechanoreceptors, sensing
external mechanical forces, including strain, stretch and fluid shear
stress, triggering a cascade of signaling pathways involved in
osteoblastogenesis and ultimately bone formation. Both in vitro studies
and research on animal models have already identified their implications
in bone homeostasis. However, uncertainty veiling the role of
polycystins (PCs) in bone disease urges studies to elucidate further
their role in this field. Mutations in TRPPs have been related to
autosomal polycystic kidney disease (ADKPD) and research groups try to
identify their role beyond their well-established contribution in kidney
disease. Such an elucidation would be beneficial for identifying
signaling pathways where polycystins are involved in bone diseases
related to exertion of mechanical forces such as osteoporosis,
osteopenia and craniosynostosis. A better understanding of the
implications of TRPPs in bone diseases would possibly lay the
cornerstone for effective therapeutic schemes.
Έτος δημοσίευσης:
2018
Συγγραφείς:
Katsianou, Maria A.
Skondra, Foteini G.
Gargalionis, Antonios N.
and Piperi, Christina
Basdra, Efthimia K.
Περιοδικό:
Annals of translational medicine
Εκδότης:
AME PUBL CO
Τόμος:
6
Αριθμός / τεύχος:
12
Λέξεις-κλειδιά:
Bone diseases; ion channels; mechanotransduction; polycystin transient
receptor potential polycystin cation channels (TRPP cation channels)
Επίσημο URL (Εκδότης):
DOI:
10.21037/atm.2018.04.10
Το ψηφιακό υλικό του τεκμηρίου δεν είναι διαθέσιμο.