Thyroid hormone receptor alpha 1 as a novel therapeutic target for tissue repair

Επιστημονική δημοσίευση - Άρθρο Περιοδικού uoadl:3180188 42 Αναγνώσεις

Μονάδα:
Ερευνητικό υλικό ΕΚΠΑ
Τίτλος:
Thyroid hormone receptor alpha 1 as a novel therapeutic target for
tissue repair
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Analogies between the damaged tissue and developing organ indicate that
a regulatory network that drives embryonic organ development may control
aspects of tissue repair. In this regard, there is a growing body of
experimental and clinical evidence showing that TH may be critical for
recovery after injury. Especially TR alpha 1 has been reported to play
an essential role in cell proliferation and differentiation and thus in
the process of repair/regeneration in the heart and other tissues.
Patients after myocardial infarction, stroke or therapeutic
interventions [such as PCI for coronary artery disease (CAD)] with
lower TH levels appear to have increased morbidity and mortality.
Accordingly, TH treatment in clinical settings of ischemia/reperfusion
such as by-pass surgery seems to be cardioprotective against ischemic
injury. Furthermore, TH therapy of donors is shown to result in organ
preservation and increased numbers of donors and improved
post-transplantation graft survival. TH and thyroid analogs may prove
novel therapeutic agents for tissue repair.
Έτος δημοσίευσης:
2018
Συγγραφείς:
Pantos, Constantinos
Mourouzis, Iordanis
Περιοδικό:
Annals of translational medicine
Εκδότης:
AME PUBL CO
Τόμος:
6
Αριθμός / τεύχος:
12
Λέξεις-κλειδιά:
Thyroid hormone (TH); thyroid hormone receptor alpha 1 (TR alpha 1);
repair; regeneration; heart failure (HF); myocardial ischemia; brain;
skeletal muscle
Επίσημο URL (Εκδότης):
DOI:
10.21037/atm.2018.06.12
Το ψηφιακό υλικό του τεκμηρίου δεν είναι διαθέσιμο.