Περίληψη:
The aim of this study was to evaluate in an experimental model of aortic
valve (AV) stenosis the effectiveness of zoledronate on the inhibition
of calcification. Sixteen New Zealand rabbits were placed on vitamin
D-enriched diet for 3 weeks. All animals underwent PET/CT at baseline
and before euthanasia to assess calcification. Thereafter, the AVs of
eight animals were treated with local delivery of 500 mu g/l
zoledronate. A placebo mixture was administered in the remaining eight
animals. Standardized uptake values were corrected for blood pool
activity, providing mean tissue to background ratios (TBRmean). In the
zoledronate group, there was no progression of AV calcification (TBRmean
1.20 +/- 0.12 vs 1.17 +/- 0.78,p = 0.29), while AV calcification
progressed in the placebo group (1.22 +/- 0.15 vs 1.53 +/- 0.23,p =
0.006). Ascending aorta (AA) calcification progressed in both
zoledronate and placebo groups. Histology confirmed the results of the
PET/CT. Inhibition of AV calcification by local delivery of zoledronate
is feasible and effective.
Συγγραφείς:
Synetos, Andreas
Toutouzas, Konstantinos
Drakopoulou, Maria and
Koutagiar, Iosif
Benetos, George
Kotronias, Rafail and
Anousakis-Vlachochristou, Nikolaos
Latsios, George
Karanasos,
Antonis
Agrogiannis, George
Metaxas, Marinos
Stathogiannis,
Konstantinos
Papanikolaou, Aggelos
Georgakopoulos, Alexandros
and Pianou, Nikoleta
Tsiamis, Eleftherios
Patsouris, Efstratios
and Papalois, Apostolos
Cokkinos, Dennis
Anagnostopoulos,
Constantinos
Tousoulis, Dimitrios
