Περίληψη:
Objectives: Culprit plaque characteristics in young patients who
experience an Acute Coronary Syndrome (ACS) evaluated by OCT (Optical
Coherence Tomography) have to be defined. The OCT-FORMIDABLE is a
multicentre retrospective registry enrolling consecutive patients with
ACS who performed OCT in 9 European centres.
Methods: Patients were divided in two groups according to age at
presentation: juvenile-ACS (age <= 50 years) and not juvenile-ACS (age >
50 years). Primary end-point was the prevalence of plaque rupture (PR).
Secondary end point was the prevalence of thin cap fibro atheroma
(TCFA), fibrocalcific and fibrotic plaque.
Results: 285 patients were included, 71 (24.9%) in juvenile-ACS group
and 215 (75.1%) in not juvenile-ACS group. Younger patients showed a
trend for a higher prevalence of TCFA (70 vs. 58%, P = 0.06) and
thrombus presence (62 vs. 51%, P = 0.1), while no statistical
difference concerning PR (70 vs. 64%, P = 0.29). Of interest patients
younger that 35 years showed a higher prevalence of PR compared to
patients aged between 35 and 45 or 45 and 50 years (100 vs. 72 vs. 55%,
P = 0.03). Culprit plaque in juvenile-ACS group showed more frequently a
reduced mean cap thickness (119 +/- 66 vs. 155 +/- 95 nm, P = 0.05) and
less frequently fibrotic (32 vs. 57%, P < 0.001) or fibrocalcific (17
vs. 36%, P = 0.003) characteristics.
Conclusions:young patients with ACS show a trend for a higher prevalence
of culprit PR, a thinner cap and less fibrotic or fibrocalcific
components.
Συγγραφείς:
Barbero, Umberto
Scacciatella, Paolo
Iannaccone, Mario and
D'Ascenzo, Fabrizio
Niccoli, Giampaolo
Colombo, Francesco and
Ugo, Fabrizio
Colangelo, Salvatore
Mancone, Massimo and
Calcagno, Simone
Sardella, Gennaro
Amabile, Nicolas
Motreff,
Pascal
Toutouzas, Konstantinos
Garbo, Roberto
Tamburino,
Corrado
Montefusco, Antonio
Omede, Pierluigi
Moretti,
Claudio
D'amico, Maurizio
Souteyrand, Geraud
Gaita, Fiorenzo
and Templin, Christian
