Περίληψη:
There are both limited and conflicting data on the role of dietary fat
and specific fatty acids in the development of pancreatic cancer. In
this study, we investigated the association between plasma phospholipid
fatty acids and pancreatic cancer risk in the European Prospective
Investigation into Cancer and Nutrition (EPIC) cohort. The fatty acid
composition was measured by gas chromatography in plasma samples
collected at recruitment from375 incident pancreatic cancer cases and375
matched controls. Associations of specific fatty acids with pancreatic
cancer risk were evaluated using multivariable conditional logistic
regression models with adjustment for established pancreatic cancer risk
factors. Statistically significant inverse associations were found
between pancreatic cancer incidence and levels of heptadecanoic acid
(ORT3-T1[odds ratio for highest versus lowest tertile] =0.63;
95%CI[confidence interval] = 0.41-0.98; p(trend) = 0.036), n-3
polyunsaturated -linolenic acid (ORT3-T1 = 0.60; 95%CI = 0.39-0.92;
p(trend) = 0.02) and docosapentaenoic acid (ORT3-T1 = 0.52; 95%CI =
0.32-0.85; p(trend) = 0.008). Industrial trans-fatty acids were
positively associated with pancreatic cancer risk among men (ORT3-T1 =
3.00; 95%CI = 1.13-7.99; p(trend) = 0.029), while conjugated linoleic
acids were inversely related to pancreatic cancer among women only
(ORT3-T1 = 0.37; 95%CI = 0.17-0.81; p(trend) = 0.008). Among current
smokers, the long-chain n-6/n-3 polyunsaturated fatty acids ratio was
positively associated with pancreatic cancer risk (ORT3-T1 = 3.40;
95%CI = 1.39-8.34; p(trend) = 0.007). Results were robust to a range of
sensitivity analyses. Our findings suggest that higher circulating
levels of saturated fatty acids with an odd number of carbon atoms and
n-3 polyunsaturated fatty acids may be related to lower risk of
pancreatic cancer. The influence of some fatty acids on the development
of pancreatic cancer may be sex-specific and modulated by smoking.
Συγγραφείς:
Matejcic, M.
Lesueur, F.
Biessy, C.
Renault, A. L. and
Mebirouk, N.
Yammine, S.
Keski-Rahkonen, P.
Li, K. and
Hemon, B.
Weiderpass, E.
Rebours, V.
Boutron-Ruault, M. C.
and Carbonnel, F.
Kaaks, R.
Katzke, V.
Kuhn, T.
Boeing,
H.
Trichopoulou, A.
Palli, D.
Agnoli, C.
Panico, S. and
Tumino, R.
Sacerdote, C.
Quiros, J. R.
Duell, E. J. and
Porta, M.
Sanchez, M. J.
Chirlaque, M. D.
Barricarte, A. and
Amiano, P.
Ye, W.
Peeters, P. H.
Khaw, K. T. and
Perez-Cornago, A.
Key, T. J.
Bueno-de-Mesquita, H. B. and
Riboli, E.
Vineis, P.
Romieu, I.
Gunter, M. J.
Chajes,
V.
