Περίληψη:
Objective: To compare non-I lodgkin lymphoma (NHL) incidence rates in
adults who started antiretroviral therapy (ART) across the Asia-Pacific,
South Africa, Europe, Latin, and North America.
Methods: We included cohort data of adults living with HIV who started
ART after 1995 within the framework of the International epidemiology
Databases to Evaluate AIDS (leDEA) and (he Collaboration of
Observational HIV Epidemiological Research in Europe (COHERE). We used
flexible parametric survival models to compare regional NHL rates at 2
years after ART start and to identify risk factors for NHL.
Results: We included 210898 adults with 1.1 million person-years (pys)
of follow-up and 1552 incident NHL cases (raw overall incidence rate
142/100000 pys). After adjusting for age at ART start, first-line ART
regimen, calendar period of ART start, and especially current CD4(+)
cell count, NHL rates were similar across regions for most population
groups. However, South African women remained at increased risk of
developing NHL compared with their European counterparts [adjusted
hazard ratio [aHR] 1.79, 95% CI 1.19-2.701. In Europe, Latin, and
North America, NHL risk was highest in MSM (aHR 1.30, 95% CI
1.14-1.48), followed by heterosexual men (referent), and women (aHR
0.66, 95% CI 0.57-0.78).
Conclusion: The risk of developing NHL is higher in women in South
Africa than in Europe and higher in MSM compared with heterosexual men
and women. Reasons for these differences remain unclear. Early ART
access and regular patient monitoring to avert low CD4(+) cell counts
remain key for NHL prevention. copyright (C) 2018 WolLers Kluwer Health,
Inc. All rights reserved.
Συγγραφείς:
Rohner, Eliane
Butikofer, Lukas
Schmidlin, Kurt
Sengayi,
Mazvita
Maskew, Mhairi
Giddy, Janet
Moore, Richard D. and
Goedert, James J.
Gill, M. John
Silverberg, Michael J. and
Patel, Pragna
Castilho, Jessica
Hoy, Jennifer
Sohn, Annette
and Bani-Sadr, Firouze
Taylor, Ninon
Paparizos, Vassilios
Le
Moing, Vincent
Bonnet, Fabrice
Verbon, Annelies
Vehreschild,
Jorg Janne
Post, Frank A.
Sabin, Caroline
Mocroft, Amanda
and Dronda, Fernando
Obel, Niels
Grabar, Sophie
Spagnuolo,
Vincenzo
Antinori, Andrea
Quiros-Rol-dan, Eugenia
Mussini,
Cristina
Miro, Jose M.
Meyer, Laurence
Hasse, Barbara and
Konopnicki, Deborah
Roca, Bernardino
Boue, Francois
Barger,
Diana
Raben, Dorthe
Clifford, Gary M.
Franceschi, Silvia and
Brockmeyer, Norbert
Egger, Matthias
Bohlius, Julia and
AIDS-Defining Cancer Project Work
