Περίληψη:
Objective The aims of this study were to determine the expression of
phosphatase and tensin homologue (PTEN) in endometrial adenocarcinomas
(as a potential prognostic indicator before treatment) in imprint smears
and to correlate the results with clinicopathological parameters of
primary untreated endometrial cancer patients. Methods Results A total
of 126 patients with endometrial carcinoma were evaluated with samples
freshly resected after a total abdominal hysterectomy during a 29-month
period. The expression of PTEN was assessed by immunocytochemistry. In
total, 102 cases were type I and 24 type II endometrial adenocarcinomas.
High expression of PTEN was more frequent in type I (42/102) compared to
type II (6/24) adenocarcinomas, to less advanced and aggressive clinical
stage (stage I: 41/79, stage II: 5/13, stage III: 2/19, stage IV: 1/15)
as well as in low grade (grade 1: 26/42, grade 2: 20/57) compared to
high-grade (grade 3: 8/27) carcinomas. The nonaffected lymph nodes
showed high expression of PTEN (in 43.3%) than the affected lymph nodes
(in 5.9%). Also, in 45 out of 74 cases with myometrial invasion <50%,
there was positive expression of PTEN in contrast to 12 out of 52 cases
with depth of myometrial invasion >50%. Conclusions Immunocytochemical
findings from PTEN stain, in addition to cytomorphological features,
appeared to be a useful marker in the diagnosis and in the postoperative
prognosis of endometrial carcinoma in endometrial cytology with imprint
smears and that high PTEN expression is related to morphological
features of less aggressiveness tumours.
Συγγραφείς:
Kosmas, Konstantinos
Mitropoulou, Georgia
Provatas, Ioannis and
Stamoulas, Marios
Marouga, Anna
