Περίληψη:
Introduction. There is an emerging interest in the literature about
MOGHE (Mild Malformation of Cortical Development with Oligodendroglial
Hyperplasia and Epilepsy). We report the case of an epileptic patient
with MOGHE. Case Report. A 33-year-old male patient was suffering from
refractory focal epilepsy since adolescence. MRI demonstrated increased
T2/FLAIR signal intensity of right frontal lobe. Presurgical evaluation
led to definition of epileptogenic network in a specific area of right
frontal lobe. The resected specimen revealed MOGHE. Discussion. MOGHE
appears to be a brain entity which shares some unique histopathological
features. Review of the literature is in accordance with our patient's
findings. The major neuropathological finding consists of areas with
blurred gray-white matter boundaries due to heterotopic neurons in white
matter and increased numbers of subcortical oligodendroglial cells with
increased proliferation. MR abnormalities are present in T2/FLAIR
sequences. It concerns patients with refractory frontal lobe epilepsy
and appears to associate with unfavourable postsurgical outcome in
seizure control. Conclusion. More cases are needed in order to establish
more data about this distinct entity in frontal lobe epilepsy. This
could be valuable knowledge to patients and doctors concerning
expectations or management of undesirable outcome in frontal lobe
epilepsy surgery.
Συγγραφείς:
Verentzioti, A.
Blumcke, I
Alexoudi, A.
Patrikelis, P. and
Siatouni, A.
Korfias, S.
Sakas, D.
Gatzonis, S.
