Τίτλος:
Biomarkers in Atrial Fibrillation and Heart Failure
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Atrial fibrillation (AF) is the most common sustained arrhythmia
encountered in clinical practice and an important contributor to
cardiovascular morbidity and mortality. Although the exact mechanisms
behind AF are not completely elucidated, the underlying
pathophysiological changes have been well described. Predisposal factors
for AF include the older age, the increased left atrial size, the
decreased left atrial function, the presence of heart failure and left
ventricular systolic dysfunction and the presence of coronary heart
disease or pulmonary or mitral valve disease. In addition to these
factors, emerging evidence demonstrate that myocardial strain, fibrosis
and inflammation, are associated with AF as well as the pathogenesis of
the arrhythmia. The natruretic peptide system including Atrial
Natriuretic Peptide (ANP), Brain Natriuretic Peptide (BNP) and C-type
Natriuretic Peptide (CNP) is indicative of the level of myocardial
strain which may predispose to AF. As a result, the aforementioned
peptides are increased in AF patients. The levels of myocardial fibrosis
biomarkers, such as ST2 and Galectin-3, are elevated suggesting atrial
structural abnormalities, while the increased levels of CRP and
Interleukin-6 supplement the inflammatory profile of AF patients.
Emerging data for the aforementioned biomarkers are discussed in the
present review.
Συγγραφείς:
Oikonomou, Evangelos
Zografos, Theodoros
Papamikroulis,
Georgios-Angelos
Siasos, Gerasimos
Vogiatzi, Georgia and
Theofilis, Panagiotis
Briasoulis, Alexandros
Papaioannou,
Spyridon
Vavuranakis, Manolis
Gennimata, Vasiliki
Tousoulis,
Dimitris
Περιοδικό:
Current Medicinal Chemistry
Εκδότης:
BENTHAM SCIENCE PUBL LTD
Λέξεις-κλειδιά:
Atrial fibrillation; natriuretic peptides; ANP; BNP; myocardial
fibrosis; ST2; Galectin-3; inflammation; CRP; IL-6
DOI:
10.2174/0929867324666170830100424
