Περίληψη:
The subject of colorectal neuroendocrine neoplasms (NENs), subdivided
into well-differentiated NENs, termed neuroendocrine tumours (NETs;
grade (G) 1 and 2), and poorly differentiated NENs, termed
neuroendocrine carcinomas (NECs; G3) according to the 2010 World Health
Organisation (WHO) classification, has arguably not had as much
attention or study as NENs occurring in other sites. Colorectal NETs and
NECs are however easier to study than many others since they are usually
not difficult to remove and are increasingly detected because of
intensified colorectal cancer screening and surveillance programmes.
Colorectal NETs and NECs show site-specific heterogeneity with variable
behaviour and different therapeutic options; these various aspects
provide unique challenges. Because of bowel cancer screening programmes,
colorectal NENs, like conventional adenocarcinomas, may be diagnosed at
a stage that is associated with improved survival. In this article we
intend to describe and define areas of unmet needs relating to the
epidemiology, classification, pathology, diagnosis and therapy of
colorectal NETs (including NETs G3), colorectal NECs, and finally, mixed
adeno-neuroendocrine carcinomas (MANECs) by reviewing and discussing the
relevant literature.
Συγγραφείς:
Ramage, John K.
Valle, Juan W.
van Dijkum, Els J. M. Nieveen and
Sundin, Anders
Pascher, Andreas
Couvelard, Anne
Kloeppel,
Guenter
Bartsch, Detlef
Arnold, Rudolf
Baudin, Eric and
Bodei, Lisa
Borbath, Iva
Capdevila, Jaume
Caplin, Matyn and
Chen, Jie
Costa, Frederico
Couvelard, Anne
Cwikla, Jaroslaw
B.
Davies, Philippa
de Herder, Wouter W.
Falconi, Massimo
and Falkerby, Jenny
Fazio, Nicola
Ferone, Diego
Frilling,
Andrea
Garcia-Carbonero, Rocio
Glasberg, Simona
Gorbunova,
Vera
Grossman, Ashley
Hoersch, Dieter
Jensen, Robert and
Kaltsas, Gregory
Kloeppel, Guenter
Kingge, Ulrich Peter and
Kos-Kudla, Beata
Krejs, Guenter J.
Krenning, Eric
Kulke,
Matthew
Lamberts, Steven W. J.
Van Dijkum, Nieveen Els J. M. and
O'Connor, Juan Manuel
O'Toole, Dermot
Pape, Ulrich-Frank and
Partelli, Stefano
Pavel, Marianne Ellen
Peeters, Marc and
Ramage, John K.
Reed, Nicholas Simon
Rindi, Guido
Rinke,
Anja
Ruszniewski, Philippe
Sorbye, Halfdan
Sundin, Anders
and Scoazec, Jean-Yves
Taal, Babs G.
Janson, Tiensuu Eva and
Toumpanakis, Christos
Valle, Juan W.
Vullierme, Marie-Pierre and
Staffan, Welin
Wiedenmann, Bertman
ENETS 2016 Munich Advisory
Board
