Τίτλος:
Intergenotypic 2k/1b hepatitis C virus recombinants in the East
Macedonia and Thrace region of Greece
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background Intergenotypic recombinant hepatitis C virus (HCV) strains
emerge rarely during coinfection of the same individual with two HCV
genotypes. Few recombinant HCV strains have been identified to date and
only one, CRF01 2k/1b, has become a worldwide concern. This study
reevaluated the genotyping of three HCV genotype 2 strains from a group
of patients with an unusually low rate of sustained virological response
after pegylated interferon/ribavirin treatment. In addition, genetic
determinants of host interferon resistance were evaluated.
Methods The HCV type 2 strains from the patients' serum were subjected
to partial sequencing of the core-E1, NS2, NS5A and NS5B regions by
reverse transcription polymerase chain reaction. Furthermore, the IFNL3
rs12979860 and the IFNL4 rs368234815 single nucleotide polymorphisms
were defined in two of the three patients.
Results All three strains were phylogenetically related to the
Russia-derived CRF01 2k/1b while they encompassed the exact same 2k/1b
junction site within NS2.
Conclusion This is the first report of HCV 2k/1b recombinants in Greece
and the greater area of the Balkans.
Συγγραφείς:
Kassela, Katerina
Karakasiliotis, Ioannis
Kokkiou, Eleni and
Souvalidou, Fani
Mimidis, Panayotis
Veletza, Stavroula and
Panopoulou, Maria
Koskinas, John
Mimidis, Konstantinos and
Mavromara, Penelope
Περιοδικό:
Annals of Gastroenterological Surgery
Εκδότης:
HELLENIC SOC GASTROENTEROLOGY
Λέξεις-κλειδιά:
Hepatitis C virus; IFN-resistance; phylogenetic analysis; recombination
DOI:
10.20524/aog.2018.0322
