Περίληψη:
Background: Alkylphenolic compounds are chemicals with endocrine
disrupting properties that have been widely used in industry with
important changes in their usage over time. Few epidemiologic studies
have evaluated the effect of alkylphenolic compounds on human health.
Objectives: We investigated whether occupational exposure to
alkylphenolic compounds is associated with breast and prostate cancer.
Methods: We carried out a population-based case-control study including
1513 incident cases of breast cancer, 1095 of prostate cancer, and 3055
controls, frequency matched by sex, age and region. Occupational
exposure to alkylphenolic compounds was estimated using a recently
developed job-exposure matrix, which considered different scenarios of
exposure and different subtypes of alkylphenolic compounds.
Results: History of occupational exposure to alkylphenolic compounds was
modestly associated with breast cancer (OR = 1.23; 95% CI = 1.01-1.48).
Within the different scenarios, the occupational use of domestic
tensioactives was positively associated with breast cancer (OR = 1.28;
95% CI = 1.02-1.60), while occupational exposure in other scenarios
showed mostly a suggestion of a similar positive associations. Exposure
to nonylphenol ethoxylates was positively associated with breast cancer
(OR = 1.21; 95% CI = 1.00-1.47), while exposure to other compounds was
uncommon. In general, we did not observe associations between
alkylphenolic compounds and prostate cancer, except for a positive
association among men occupationally exposed to cosmetic, hair and
personal hygiene products.
Conclusions: Our findings suggest a modest association between breast
cancer risk and occupational exposure to alkylphenolic compounds, and no
associations between these compounds and prostate cancer risk. These
findings warrant further corroboration in other studies.
Συγγραφείς:
Peremiquel-Trillas, Paula
Benavente, Yolanda
Martin-Bustamante,
Mayte
Casabonne, Delphine
Perez-Gomez, Beatriz
Gomez-Acebo,
Ines
Oliete-Canela, Anna
Dieguez-Rodriguez, Marta
Tusquets,
Ignasi
Amiano, Pilar
Mengual, Lourdes
Ardanaz, Eva and
Capelo, Rocio
Molina de la Torre, Antonio J.
Salas Trejo,
Dolores
Fernandez-Tardon, Guillermo
Lope, Virginia and
Jimenez-Moleon, Jose J.
Marcos-Gragera, Rafael
Dierssen-Sotos,
Trinidad
Azpiri, Mikel
Munoz, Montse
Guevara, Marcela and
Fernandez-Villa, Tania
Molina-Barcelo, Ana
Aragones, Nuria and
Pollan, Marina
Castano-Vinyals, Gemma
Alguacil, Juan and
Kogevinas, Manolis
de Sanjose, Silvia
Costas, Laura
