Ερευνητικό υλικό ΕΚΠΑ

High Rates of Prescribing Antimicrobials for Prophylaxis in Children and
Neonates: Results From the Antibiotic Resistance and Prescribing in
European Children Point Prevalence Survey

Αγγλικά

Background. This study was conducted to assess the variation in
prescription practices for systemic antimicrobial agents used for
prophylaxis among pediatric patients hospitalized in 41 countries
worldwide.
Methods. Using the standardized Antibiotic Resistance and Prescribing in
European Children Point Prevalence Survey protocol, a cross-sectional
point-prevalence survey was conducted at 226 pediatric hospitals in 41
countries from October 1 to November 30, 2012.
Results. Overall, 17 693 pediatric patients were surveyed and 36.7% of
them received antibiotics (n = 6499). Of 6818 inpatient children, 2242
(32.9%) received at least 1 antimicrobial for prophylactic use. Of 11
899 prescriptions for antimicrobials, 3400 (28.6%) were provided for
prophylactic use. Prophylaxis for medical diseases was the indication in
73.4% of cases (2495 of 3400), whereas 26.6% of prescriptions were for
surgical diseases (905 of 3400). In approximately half the cases (48.7%
[1656 of 3400]), a combination of 2 or more antimicrobials was
prescribed. The use of broad-spectrum antibiotics (BSAs), which included
tetracyclines, macrolides, lincosamides, and sulfonamides/trimethoprim,
was high (51.8% [1761 of 3400]). Broad-spectrum antibiotic use for
medical prophylaxis was more common in Asia (risk ratio [RR], 1.322;
95% confidence interval [CI], 1.202-1.653) and more restricted in
Australia (RR, 0.619; 95% CI, 0.521-0.736). Prescription of BSA for
surgical prophylaxis also varied according to United Nations region.
Finally, a high percentage of surgical patients (79.7% [721 of 905])
received their prophylaxis for longer than 1 day.
Conclusions. A high proportion of hospitalized children received
prophylactic BSAs. This represents a clear target for quality
improvement. Collectively speaking, it is critical to reduce total
prophylactic prescribing, BSA use, and prolonged prescription.

2019

Hufnagel, Markus
Versporten, Ann
Bielicki, Julia
Drapier,
Nico
Sherland, Mike
Goossens, Herman
Maria Calle, Graciela
and Clark, Julia
Cooper, Celia
Blyth, Christopher C. and
Francis, Joshua Reginald
Alsalman, Jameela
Jansen, Hilde and
Mahieu, Ludo
Van Rossom, Paul
Vandewal, Wouter
Lepage,
Philippe
Blumental, Sophie
Briquet, Caroline
Robbrecht, Dirk
and Maton, Pierre
Gabriels, Patrick
Rubic, Zana
Kovacevic,
Tanja
Nielsen, Jens Peter
Petersen, Jes Reinholdt and
Poorisrisak, Porntiva
Jensen, Lise Heilmann
Laan, Mari
Tamm,
Eda
Matsinen, Maire
Rummukainen, Maija-Liisa
Gajdos, Vincent
and Olivier, Romain
Le Marechal, Flore
Martinot, Alain and
Dubos, Francois
Lagree, Marion
Prot-Labarthe, Sonia
Lorrot,
Mathie
Orbach, Daniel
Pagava, Karaman
Knuf, Markus and
Schlag, Stephanie A. A.
Liese, Johannes
Renner, Lorna and
Enimil, Anthony
Awunyo, Marah
Syridou, Garyfallia
Spyridis,
Nikos
Critselis, Elena
Kouni, Sofia
Mougkou, Katerina and
Ladomenou, Fani
Gkentzi, Despoina
Iosifidis, Elias
Roilides,
Emmanuel
Sahu, Suneeta
Murki, Srinivas
Malviya, Manoj and
Kalavalapalli, Durga Bhavani
Singh, Sanjeev
Singhal, Tanu and
Garg, Garima
Garg, Pankaj
Kler, Neelam
Soltani, Jafar and
Jafarpour, Zahra
Pouladfar, Gholamreza
Nicolini, Giangiacomo and
Montagnani, Carlotta
Galli, Luisa
Esposito, Susanna
Tenconi,
Rossana
Lo Vecchio, Andrea
Dona, Daniele
Giaquinto, Carlo
and Borgia, Eleonora
D'Argenio, Patrizia
De Luca, Maia and
Centenari, Chiara
Raka, Lul
Raka, Denis
Omar, Abeer and
Al-Mousa, Haifaa
Mozgis, Dzintars
Sviestina, Inese and
Burokiene, Sigita
Usonis, Vytautas
Tavchioska, Gabriela and
Hargadon-Lowe, Antonia
Zarb, Peter
Borg, Michael A.
Gonzalez
Lozano, Carlos Agustin
Zarate Castanon, Patricia
Cancino, Martha
E.
McCullagh, Bernadette
McCorry, Ann
Gormley, Cairine and
Al Maskari, Zaina
Al-Jardani, Amina
Pluta, Magdalena and
Rodrigues, Fernanda
Brett, Ana
Esteves, Isabel
Marques,
Laura
AlAjmi, Jameela Ali
Cambrea, Simona Claudia
Rashed,
Asia N.
Al Azmi, Aeshah Abdu Mubarak
Chan, Si Min
Isa, Mas
Suhaila
Najdenov, Peter
Cizman, Milan
Unuk, Sibila and
Finlayson, Heather
Dramowski, Angela
Mate-Cano, Irene
Soto,
Beatriz
Calvo, Cristina
Santiago, Begona
Saavedra-Lozano,
Jesus
Bustinza, Amaya
Escosa-Garcia, Luis
Ureta, Noelia and
Lopez-Varela, Elisa
Rojo, Pablo
Tagarro, Alfredo
Terol
Barrero, Pedro
Maria Rincon-Lopez, Elena
Abubakar, Ismaela and
Aston, Jeff
Patel, Mitul
Russell, Alison Bedford and
Heginbothom, Maggie
Satodia, Prakash
Garbash, Mehdi
Johnson,
Alison
Sharpe, David
Barton, Christopher
Menson, Esse and
Arenas-Lopez, Sara
Luck, Suzanne
Doerholt, Katja
McMaster,
Paddy
Caldwell, Neil A.
Lunn, Andrew
Drysdale, Simon B. and
Howe, Rachel
Scorrer, Tim
Gahleitner, Florian
Gupta, Richa
and Nash, Clare
Alexander, John
Raman, Mala
Bell, Emily and
Rajagopal, Veena
Kohlhoff, Stephan
Cox, Elaine
Nichols,
Kristen
Zaoutis, Theoklis
ARPEC Project Grp

Journal of the Pediatric Infectious Diseases Society

Oxford University Press

8

2

143-151

antimicrobials; inpatients; pediatrics; point-prevalence survey;
prophylactic prescribing

https://doi.org/10.1093/jpids/piy019

10.1093/jpids/piy019

https://pergamos.lib.uoa.gr/uoa/dl/object/3184189