Περίληψη:
The burden of paediatric Hepatitis C virus (HCV) infection across Europe
is unknown, as are current policies regarding monitoring and treatment.
This collaborative study aimed to collect aggregate data to characterise
the population of <= 18-year-olds with HCV infection in specialist
follow up in a 12-month period (2016) across the PENTAHep European
consortium, and investigate current policies around monitoring and
treatment. A cross-sectional, web-based survey was distributed in April
2017 to 50 paediatricians in 19 European countries, covering patients’
profile, and monitoring and treatment practices. Responses were received
from 38/50 clinicians collectively caring for 663 children with chronic
HCV infection of whom three-quarters were aged >= 6 years and 90%
vertically infected. HCV genotype 1 was the most common (n 380; 57.3%),
followed by genotype 3, 4 and 2. Seventeen children (3%) with chronic
HCV infection were diagnosed with cirrhosis, and six were reported to
have received liver transplantation for HCV-related liver disease. The
majority (n 425; 64.1%) of the European children with HCV infection
remained treatment-naive in 2016. Age affected clinicians’ attitudes
towards treatment; 94% reported being willing to use direct-acting
antivirals, if available, in adolescents (aged >= 11 years), 78% in
children aged 6-10 and 42% in those 3-5 years of age (Pearson
correlation coefficient -0.98; P 0.0001). This survey provides the
largest characterisation of the population of children in clinical
follow-up for chronic HCV infection in Europe, alongside important
contextual information on their management and treatment. Discussion is
needed around strategies and criteria for use of direct-acting
antivirals in these children.
Συγγραφείς:
Indolfi, Giuseppe
Bailey, Heather
Serranti, Daniele and
Giaquinto, Carlo
Thorne, Claire
Indolfi, Giuseppe
Bailey,
Heather
Serranti, Daniele
Giaquinto, Carlo
Thorne, Claire
and Jahnel, Joerg
Sokal, Etienne
Lamireau, Thierry
Lacaille,
Florence
Debray, Dominique
Girard, Muriel
Feiterna-Sperling,
Cornelia
Wirth, Stefan
Vassiliki, Papaevangelou
Dezsofi,
Antal
Guidi, Roberto
Verucchi, Gabriella
D'Antiga, Lorenzo
and Nicastro, Emanuele
Maggiore, Giuseppe
Trapani, Sandra and
Ricci, Silvia
Resti, Massimo
Giacomet, Vania
Benincaso, Anna
Rita
Nebbia, Gabriella
Iorio, Raffaele
Cananzi, Mara and
Riva, Silvia
Bossi, Grazia
Dodi, Icilio
Nobili, Valerio and
Comparcola, Donatella
Garazzino, Silvia
Calvo, Pier Luigi and
Pokorska-Spiewak, Maria
Pawlowska, Malgorzata
Goncalves,
Cristina
Goncalves, Isabel
Tudor, Ana Maria
Noguera-Julian,
Antoni
Hierro, Loreto
Ramos, Jose T.
Fischler, Bjorn and
McLin, Valerie
Kansu, Aydan
Brown, Maxine
Kelly, Deirdre and
Davison, Suzanne
Turkova, Anna
Bamford, Alasdair
PENTAHep
Study Grp
