Τίτλος:
Combined study on the single nucleotide polymorphisms in the
follicle-stimulating hormone receptor (Ser680Asn) and anti-Mullerian
hormone receptor type II (-482A>G) as genetic markers in assisted
reproduction
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: Infertile women may have underlying genetic abnormalities.
There is, at present, a significant number of studies on the relation
between the follicle stimulating hormone receptor (FSHR) or
anti-Mullerian hormone type II receptor (AMHRII) polymorphisms and
response to in-vitro fertilisation (IVF) treatment. However, it is not
yet clear which genotype or combination of genotypes is favourable
towards a better ovarian stimulation and pregnancy outcome.
Materials and methods: In this study we assessed the distribution of the
genotypes of FSHR Ser680Asn and of AMHRII -482A>G gene polymorphisms in
a group of 126 infertile women and a control group of 100 fertile women
by using real-time polymerase chain reaction (RT-PCR).
Results: Statistical analysis showed that the frequency of the genotypes
is similar in both control and IVF/ intracytoplasmic sperm injection
(ICSI) groups. Further investigation of the frequency of the nine
possible combinations of these polymorphisms in the groups revealed no
correlation between infertility and combination of the polymorphisms.
Women with one polymorphism have on average 5.5 units higher levels of
AMH compared to women carrying no polymorphism. In women with no
polymorphisms, for each unit of FSH increase, the average concentration
of blood AMH is expected to be 72% lower.
Conclusion: The distribution of the FSHR Ser680Asn and of the AMHRII
-482A>G gene polymorphisms, in the Greek population is similar in
fertile and infertile women. The study showed that FSH and AMH
correlated levels in certain cases could be used to estimate a patient’s
ovarian reserve.
Συγγραφείς:
Papanikolaou, Ioannis C.
Giannelou, Polina
Anagnostou, Elli and
Mavrogianni, Despoina
Drakakis, Petros
Loutradis, Dimitrios
Περιοδικό:
Hormone Molecular Biology and Clinical Investigation
Εκδότης:
Walter de Gruyter GmbH
Λέξεις-κλειδιά:
AMH; AMHRII; ART; FSH; FSHR; genetic markers; SNPs
DOI:
10.1515/hmbci-2018-0077
