Περίληψη:
Asthma is a common illness throughout the world that affects the
respiratory system function, i.e., a system whose operational adequacy
determines the respiratory gases exchange. It is therefore expected that
acute severe asthma will be associated with respiratory acid-base
disorders. In addition, the resulting hypoxemia along with the
circulatory compromise due to heart-lung interactions can reduce tissue
oxygenation, with a particular impact on respiratory muscles that have
increased energy needs due to the increased workload. Thus, anaerobic
metabolism may ensue, leading to lactic acidosis. Additionally, chronic
hypocapnia in asthma can cause a compensatory drop in plasma bicarbonate
concentration, resulting in non-anion gap acidosis. Indeed, studies have
shown that in acute severe asthma, metabolic acid-base disorders may
occur, i.e., high anion gap or non-anion gap metabolic acidosis. This
review briefly presents studies that have investigated acid-base
disorders in asthma, with comments on their underlying pathophysiology.
Συγγραφείς:
Vasileiadis, Ioannis
Alevrakis, Emmanouil
Ampelioti, Sevasti and
Vagionas, Dimitrios
Rovina, Nikoletta
Koutsoukou, Antonia
