Gene expression imputation across multiple brain regions provides insights into schizophrenia risk

Επιστημονική δημοσίευση - Άρθρο Περιοδικού uoadl:3186513 90 Αναγνώσεις

Μονάδα:
Ερευνητικό υλικό ΕΚΠΑ
Τίτλος:
Gene expression imputation across multiple brain regions provides
insights into schizophrenia risk
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Transcriptomic imputation approaches combine eQTL reference panels with
large-scale genotype data in order to test associations between disease
and gene expression. These genic associations could elucidate signals in
complex genome-wide association study (GWAS) loci and may disentangle
the role of different tissues in disease development. We used the
largest eQTL reference panel for the dorso-lateral prefrontal cortex
(DLPFC) to create a set of gene expression predictors and demonstrate
their utility. We applied DLPFC and 12 GTEx-brain predictors to 40,299
schizophrenia cases and 65,264 matched controls for a large
transcriptomic imputation study of schizophrenia. We identified 413
genic associations across 13 brain regions. Stepwise conditioning
identified 67 non-MHC genes, of which 14 did not fall within previous
GWAS loci. We identified 36 significantly enriched pathways, including
hexosaminidase-A deficiency, and multiple porphyric disorder pathways.
We investigated developmental expression patterns among the 67 non-MHC
genes and identified specific groups of pre- and postnatal expression.
Έτος δημοσίευσης:
2019
Συγγραφείς:
Huckins, Laura M.
Dobbyn, Amanda
Ruderfer, Douglas M. and
Hoffman, Gabriel
Wang, Weiqing
Pardinas, Antonio F. and
Rajagopal, Veera M.
Als, Thomas D.
Nguyen, Hoang T.
Girdhar,
Kiran
Boocock, James
Roussos, Panos
Fromer, Menachem and
Kramer, Robin
Domenici, Enrico
Gamazon, Eric R.
Purcell,
Shaun
Demontis, Ditte
Borglum, Anders D.
Walters, James T.
R.
O'Donovan, Michael C.
Sullivan, Patrick
Owen, Michael J.
and Devlin, Bernie
Sieberts, Solveig K.
Cox, Nancy J.
Im,
Hae Kyung
Sklar, Pamela
Stahl, Eli A.
Johnson, Jessica S.
and Shah, Hardik R.
Klein, Lambertus L.
Dang, Kristen K. and
Logsdon, Benjamin A.
Mahajan, Milind C.
Mangravite, Lara M. and
Toyoshiba, Hiroyoshi
Gur, Raquel E.
Hahn, Chang-Gyu
Schadt,
Eric
Lewis, David A.
Haroutunian, Vahram
Peters, Mette A.
and Lipska, Barbara K.
Buxbaum, Joseph D.
Hirai, Keisuke and
Perumal, Thanneer M.
Essioux, Laurent
Rajagopal, Veera
Manikandan
Mattheisen, Manuel
Grove, Jakob
Werge, Thomas and
Mortensen, Preben Bo
Pedersen, Carsten Bocker
Agerbo, Esben and
Pedersen, Marianne Giortz
Mors, Ole
Nordentoft, Merete and
Hougaard, David M.
Bybjerg-Grauholm, Jonas
Baekvad-Hansen, Marie
and Hansen, Christine Soholm
Ripke, Stephan
Neale, Benjamin M.
and Corvin, Aiden
Farh, Kai-How
Holmans, Peter A.
Lee, Phil
and Bulik-Sullivan, Brendan
Collier, David A.
Huang, Hailiang
and Pers, Tune H.
Agartz, Ingrid
Albus, Margot
Alexander,
Madeline
Amin, Farooq
Bacanu, Silviu A.
Begemann, Martin and
Belliveau, Jr., Richard A.
Bene, Judit
Bergen, Sarah E. and
Bevilacqua, Elizabeth
Bigdeli, Tim B.
Black, Donald W. and
Bruggeman, Richard
Buccola, Nancy G.
Buckner, Randy L. and
Byerley, William
Cahn, Wiepke
Cai, Guiqing
Campion,
Dominique
Cantor, Rita M.
Carr, Vaughan J.
Carrera, Noa and
Catts, V, Stanley
Chambert, Kimberly D.
Chan, Raymond C. K. and
Chen, Ronald Y. L.
Chen, Eric Y. H.
Cheng, Wei
Cheung, Eric
F. C.
Chong, Siow Ann
Cloninger, C. Robert
Cohen, David and
Cohen, Nadine
Cormican, Paul
Craddock, Nick
Crowley, James
J.
Curtis, David
Davidson, Michael
Davis, Kenneth L. and
Degenhardt, Franziska
Del Favero, Jurgen
Dikeos, Dimitris and
Dinan, Timothy
Djurovic, Srdjan
Donohoe, Gary
Drapeau,
Elodie
Duan, Jubao
Dudbridge, Frank
Durmishi, Naser and
Eichhammer, Peter
Eriksson, Johan
Escott-Price, Valentina and
Essioux, Laurent
Fanous, Ayman H.
Farrell, Martilias S. and
Frank, Josef
Franke, Lude
Freedman, Robert
Freimer, Nelson
B.
Friedl, Marion
Friedman, I, Joseph
Fromer, Menachem and
Genovese, Giulio
Georgieva, Lyudmila
Giegling, Ina and
Giusti-Rodriguez, Paola
Godard, Stephanie
Goldstein, I,
Jacqueline
Golimbet, Vera
Gopal, Srihari
Gratten, Jacob and
de Haan, Lieuwe
Hammer, Christian
Hamshere, Marian L. and
Hansen, Mark
Hansen, Thomas
Haroutunian, Vahram
Hartmann,
Annette M.
Henskens, Frans A.
Herms, Stefan
Hirschhorn, Joel
N.
Hoffmann, Per
Hofman, Andrea
Hollegaard, V, Mads and
Ikeda, Masashi
Joa, Inge
Julia, Antonio
Kahn, Rene S. and
Kalaydjieva, Luba
Karachanak-Yankova, Sena
Karjalainen, Juha and
Kavanagh, David
Keller, Matthew C.
Kennedy, James L. and
Khrunin, Andrey
Kim, Yunjung
Klovins, Janis
Knowles, James
A.
Konte, Bettina
Kucinskas, Vaidutis
Kucinskiene, Zita
Ausrele
Kuzelova-Ptackova, Hana
Kahler, Anna K.
Laurent,
Claudine
Keong, Jimmy Lee Chee
Lee, S. Hong
Legge, Sophie E.
and Lerer, Bernard
Li, Miaoxin
Li, Tao
Liang, Kung-Yee and
Lieberman, Jeffrey
Limborska, Svetlana
Loughland, Carmel M. and
Lubinski, Jan
Lonnqvist, Jouko
Macek, Jr., Milan
Magnusson,
Patrik K. E.
Maher, Brion S.
Maier, Wolfgang
Mallet, Jacques
and Marsal, Sara
Mattingsdal, Morten
McCarley, Robert W. and
McDonald, Colm
McIntosh, Andrew M.
Meier, Sandra
Meijer,
Carin J.
Melegh, Bela
Melle, Ingrid
Mesholam-Gately, I,
Raquelle
Metspalu, Andres
Michie, Patricia T.
Milani, Lili
and Milanova, Vihra
Mokrab, Younes
Morris, Derek W.
Mors,
Ole
Murphy, Kieran C.
Murray, Robin M.
Myin-Germeys, Inez
and Muller-Myhsok, Bertram
Nelis, Mari
Nenadic, Igor and
Nertney, Deborah A.
Nestadt, Gerald
Nicodemus, Kristin K. and
Nikitina-Zake, Liene
Nisenbaum, Laura
Nordin, Annelie and
O'Callaghan, Eadbhard
O'Dushlaine, Colm
O'Neill, F. Anthony and
Oh, Sang-Yun
Olincy, Ann
Olsen, Line
Van Os, Jim and
Pantelis, Christos
Papadimitriou, George N.
Papiol, Sergi and
Parkhomenko, Elena
Pato, Michele T.
Paunio, Tiina and
Pejovic-Milovancevic, Milica
Perkins, Diana O.
Pietilainen, Olli
and Pimm, Jonathan
Pocklington, Andrew J.
Powell, John and
Price, Alkes
Pulver, Ann E.
Purcell, Shaun M.
Quested, Digby
and Rasmussen, Henrik B.
Reichenberg, Abraham
Reimers, Mark A.
and Richards, Alexander L.
Roffman, Joshua L.
Ruderfer, Douglas
M.
Salomaa, Veikko
Sanders, Alan R.
Schall, Ulrich and
Schubert, Christian R.
Schulze, Thomas G.
Schwab, Sibylle G. and
Scolnick, Edward M.
Scott, Rodney J.
Seidman, Larry J.
Shi,
Jianxin
Sigurdsson, Engilbert
Silagadze, Teimuraz
Silverman,
Jeremy M.
Sim, Kang
Slominsky, Petr
Smoller, Jordan W. and
So, Hon-Cheong
Spencer, Chris C. A.
Stefansson, Hreinn and
Steinberg, Stacy
Stogmann, Elisabeth
Straub, Richard E. and
Strengman, Eric
Strohmaier, Jana
Stroup, T. Scott and
Subramaniam, Mythily
Suvisaari, Jaana
Svrakic, Dragan M. and
Szatkiewicz, Jin P.
Soderman, Erik
Thirumalai, Srinivas and
Toncheva, Draga
Tosato, Sarah
Veijola, Juha
Waddington, John
and Walsh, Dermot
Wang, Dai
Wang, Qiang
Webb, Bradley T. and
Weiser, Mark
Wildenauer, Dieter B.
Williams, Nigel M. and
Williams, Stephanie
Witt, Stephanie H.
Wolen, Aaron R.
Wong,
Emily H. M.
Wormley, Brandon K.
Xi, Hualin Simon
Zai,
Clement C.
Zheng, Xuebin
Zimprich, Fritz
Wray, Naomi R. and
Stefansson, Kari
Visscher, Peter M.
Adolfsson, Rolf and
Andreassen, Ole A.
Blackwood, Douglas H. R.
Bramon, Elvira and
Buxbaum, Joseph D.
Borglum, Anders D.
Cichon, Sven
Darvasi,
Ariel
Domenici, Enrico
Ehrenreich, Hannelore
Esko, Tonu and
Gejman, V, Pablo
Gill, Michael
Gurling, Hugh
Hultman,
Christina M.
Iwata, Nakao
Jablensky, V, Assen
Jonsson, Erik
G.
Kendler, Kenneth S.
Kirov, George
Knight, Jo
Lencz,
Todd
Levinson, Douglas F.
Li, Qingqin S.
Liu, Jianjun and
Malhotra, Anil K.
McCarroll, Steven A.
McQuillin, Andrew and
Moran, Jennifer L.
Mortensen, Preben B.
Mowry, Bryan J. and
Nothen, Markus M.
Ophoff, Roel A.
Owen, Michael J.
Palotie,
Aarno
Pato, Carlos N.
Petryshen, Tracey L.
Posthuma,
Danielle
Rietschel, Marcella
Riley, Brien P.
Rujescu, Dan
and Sham, Pak C.
St Clair, David
Weinberger, Daniel R. and
Wendland, Jens R.
Werge, Thomas
Daly, Mark J.
Sullivan,
Patrick F.
CommonMind Consortium
Psychiat Genomics Consortium
and iPSYCH-GEMS Schizophrenia Working
Περιοδικό:
Nature Genetics
Εκδότης:
Lithuanian Nature Research Centre
Τόμος:
51
Αριθμός / τεύχος:
4
Σελίδες:
659+
Επίσημο URL (Εκδότης):
DOI:
10.1038/s41588-019-0364-4
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