Περίληψη:
Background and purpose A composite instrument able to rapidly and
reliably assess the most relevant motor and non-motor afflictions
suffered by Parkinson’s disease (PD) patients in a real world clinic
setting is an unmet need. The recently validated PD Composite Scale
(PDCS) was designed to fulfil this gap as a quick, comprehensive PD
assessment. The objective of this study was extensive evaluation of the
PDCS’s clinimetric properties using a large international sample.
Methods This was a cross-sectional study in which the PDCS, the Movement
Disorder Society Unified Parkinson’s Disease Rating Scale and the
Clinical Impression of Severity Index for PD were applied. Basic
clinimetric attributes of the PDCS were analysed. Results In total, 776
PD patients were included. The PDCS total score showed negligible floor
and ceiling effects. Three factors (54.5% of the variance) were
identified: factor 1 included motor impairment, fluctuations and
disability; factor 2, non-motor symptoms; and factor 3, tremor and
complications of therapy. Cronbach’s alpha was from 0.66 to 0.79.
Inter-rater reliability showed weighted kappa values from 0.79 to 0.98
for items and intraclass correlation coefficient values from 0.95
(Disability) to 0.99 (Motor and total score). The Bland-Altmann method,
however, showed irregular concordance. PDCS standard error of
measurement and convergent validity with equivalent constructs of other
measures were satisfactory (>= 0.70). PDCS scores significantly differed
by Hoehn and Yahr stage. Conclusion Overall, in line with previous
findings, the PDCS is a feasible, acceptable, valid, reliable and
precise instrument for quickly and comprehensively assessing PD
patients.
Συγγραφείς:
Martinez-Martin, P.
Radicati, F. G.
Rodriguez Blazquez, C. and
Wetmore, J.
Kovacs, N.
Chaudhuri, K. Ray
Stocchi, F. and
Vuletic, Vladimira
Falup-Pecurariu, Cristian
Diaconu, Stefania
and Johansson, Anders
Sundgren, Mathias
Simitsi, Athima and
Stefanis, Leonidas
Gurevich, Tanya
Migirov-Sanderovich, Angel
and Ezra, Adi
Guekht, Alla
Popov, Georgy
Stamelou, Maria and
Giagkou, Nikolaos
Stefani, Alessandro
Cerroni, Rocco
Corbo,
Massimo
Grassi, Andrea
Dellaporta, Dionysia
Tsolaki, Magda
and Ariadne, Vakirli
Kefalopoulou, Zinovia
Ellul, John
Mir,
Pablo
Adarmes, Astrid D.
Mendez-del-Barrio, Carlota and
Skorvanek, Matej
Necpal, Jan
Bostantjopoulou, Sevasti
Zoe,
Katsarou
Minar, Michal
Simu, Mihaela
Rosca, Cecilia and
Popovici, Maria
Kostic, Vladimir S.
Marti, Maria J. and
Planelles, Lluis
Kovacs, Norbert
Aschermann, Zsuzsanna and
Juhasz, Annamaria
Harmat, Mark
PDCS European Study Grp
