Τίτλος:
Treatment with Molgramostim (Recombinant Human Granulocyte-Macrophage
Colony Stimulating Factor, Rhugm-Csf, Mielogen) and Lenograstim
(Granulocyte-Colony Stimulating Factor) Improves Experimental Colitis in
Rats
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background/Aim. Treatment with growth factors could be beneficial in
both inflammatory bowel disease and experimental colitis. The aim of
this study was to investigate the effect of Colony Stimulating Factor
(CSF), and Recombinant Human (rHu) Granulocyte Stimulating Factor (GSF)
in experimental colitis in rats. Methods. Experimental colitis was
induced in 62 male Wistar rats, divided into 9 groups, using
2,4,6-trinitrobenzensulfonic acid (TNBS). Group 1: Ten rats with colitis
without treatment (control group). Euthanasia after 15 days. Group 2:
Ten animals with colitis without treatment (control group). Euthanasia
after 30 days. Group 3: Six animals with colitis. Immediate treatment
with CSF. Euthanasia after 19 days. Group 4: Six animals with colitis.
Treatment started 7 days after the induction of colitis. Animals were
kept for 19 days. Group 5: Six animals with colitis. Treatment started 2
weeks after the induction of colitis. Group 6: Six animals with colitis,
the same as in group 3. Treatment with GSF. Group 7: Six animals with
colitis, the same as in group 4. Treatment with GSF. Group 8. Six
animals with colitis, the same as in group 5. Treatment with GSF. Group
9: Six animals with colitis. Immediate treatment with prednisolone.
Euthanasia after 15 days. Results. CSF and GSF administration
significantly improved the histological score (P < 0.05) and reduced
malondialdehyde contents (P < 0.05), compared to control groups in all
animals. CSF was superior to GSF and to prednisolone. Conclusion.
Administration of both CSF and GSF could significantly improve the
histological score and oxidative stress in experimental colitis in rats.
Συγγραφείς:
Papalois, Apostolos E.
Barbatis, Calypso
Chrysikos, Dimosthenis
and Korontzi, Maria
Sideris, Michail
Pittaras, Theodoros and
Triantafyllidi, Eleni
Nomikos, Alexandros
Triantafillidis, John
K.
Περιοδικό:
BioMed Research International
DOI:
10.1155/2019/8298192
