Τίτλος:
Antithrombotic Therapy in Carotid Artery Disease
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
The management of asymptomatic atherosclerotic carotid artery disease
and the role of antithrombotic therapy is of increasing importance for
stroke prevention. Non-invasive imaging of carotid plaques can identify
high-risk plaque features that are associated with the risk of plaque
rupture. Carotid plaque necrosis, hemorrhage, fibrous cap thinning, and
the presence of foam cells have all been correlated with the risk of
rupture and onset of neurological symptoms in patients with carotid
stenosis. Antiplatelets are currently recommended for patients with a
history of ischemic stroke and/or significant carotid artery stenosis,
with aspirin and clopidogrel being the most widely used and studied
agents. The role of dual antiplatelet therapy remains controversial.
Moreover, there is scarce evidence on the role of newer anticoagulant
agents in stable patients with carotid artery stenosis. In this review
article, we discuss the pathophysiology of carotid atherosclerosis, the
use of non-invasive imaging for detecting the vulnerable carotid plaque
and summarize the existing clinical evidence on the use of antiplatelet
and antithrombotic agents in carotid artery disease.
Συγγραφείς:
Papanikolaou, Paraskevi
Antonopoulos, Alexios S.
Mastorakou,
Irene
Angelopoulos, Andreas
Kostoula, Efthalia
Mystakidi,
Xara-Vasiliki
Simantiris, Spyros
Galiatsatos, Nikolaos and
Oikonomou, Evangelos
Tousoulis, Dimitris
Περιοδικό:
Current Pharmaceutical Design
Εκδότης:
BENTHAM SCIENCE PUBL LTD
Λέξεις-κλειδιά:
Antithrombotic therapy; carotid artery disease; vulnerable carotid
plaque; antiplatelet therapy; anticoagulants; peripheral artery disease
DOI:
10.2174/1381612826666200518111359
