Τίτλος:
25-hydroxyvitamin D levels in patients with obstructive sleep apnea and
continuous positive airway pressure treatment: a brief review
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
The aim of the present study is to summarize the information available,
to time, regarding the relationship between obstructive sleep apnea
(OSA) and vitamin-D (vD) levels. Moreover, the association between vD
deficiency and OSA severity will also be examined. At the end of the
present study the possible advantageous effect of CPAP on vD-levels will
be summarized. Extensive literature search was conducted in PubMed,
Scopus, The Cochrane Library and Embase database. 13 articles were found
concerning OSA and vD, of which 2 articles included treatment with a
CPAP. Patients with OSA exhibit low levels of vD in the blood serum, and
women present an even lower mean value than men. Lack of VD in blood
serum seems to be related to the severity of the OSA syndrome, and to
the short duration of sleep. OSA patients with concurrent metabolic
syndrome exhibit lower serum vD-levels, as compared with those without
metabolic syndrome. Long-term continuous positive airway pressure
treatment (CPAP) treatment can increase vD-levels in male OSA patients
while no change is observed in women. OSA patients demonstrate lower
levels of vD in multiple studies. The severity of the OSA may be
associated with vD-levels and deficiency, however more studies are
needed to assess that relationship due to contradictions in current
bibliography. CPAP can increase vD-levels in male patients. The relation
between vD and OSA and/or CPAP is important but recent; therefore
further research is needed about the exact relationship to be clarified.
Also, the effect of gender hormones on vD regulation in OSA patients
should be further investigated.
Συγγραφείς:
Siachpazidou, I, Dimitra
Stavrou, Vasileios
Zouridis, Spyridon
and Gogou, Eudoxia
Economou, Nicholas-Tiberio
Pastaka, Chaido
and Hatzoglou, Chrissi
Gourgoulianis, I, Konstantinos
Εκδότης:
BRAZILIAN ASSOC SLEEP
Λέξεις-κλειδιά:
Obstructive Sleep Apnea; Vitamin D; Continuous Positive Airway Pressure
Treatment; Adults
DOI:
10.5935/1984-0063.20190126
