Περίληψη:
Coronavirus disease 2019 (COVID-19), currently a worldwide pandemic, is
a viral illness caused by the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2). The suspected contribution of thrombotic
events to morbidity and mortality in COVID-19 patients has prompted a
search for novel potential options for preventing COVID-19-associated
thrombotic disease. In this article by the Global COVID-19 Thrombosis
Collaborative Group, we describe novel dosing approaches for commonly
used antithrombotic agents (especially heparin-based regimens) and the
potential use of less widely used antithrombotic drugs in the absence of
confirmed thrombosis. Although these therapies may have direct
antithrombotic effects, other mechanisms of action, including
anti-inflammatory or antiviral effects, have been postulated. Based on
survey results from this group of authors, we suggest research
priorities for specific agents and subgroups of patients with COVID-19.
Further, we review other agents, including immunomodulators, that may
have antithrombotic properties. It is our hope that the present document
will encourage and stimulate future prospective studies and randomized
trials to study the safety, efficacy, and optimal use of these agents
for prevention or management of thrombosis in COVID-19.
Συγγραφείς:
Bikdeli, Behnood
Madhavan, Mahesh V.
Gupta, Aakriti
Jimenez,
David
Burton, John R.
Nigoghossian, Caroline Der
Chuich,
Taylor
Nouri, Shayan Nabavi
Dreyfus, Isaac
Driggin, Elissa
and Sethi, Sanjum
Sehgal, Kartik
Chatterjee, Saurav
Ageno,
Walter
Madjid, Mohammad
Guo, Yutao
Tang, Liang V.
Hu, Yu
and Bertoletti, Laurent
Giri, Jay
Cushman, Mary
Quere,
Isabelle
Dimakakos, Evangelos P.
Gibson, C. Michael
Lippi,
Giuseppe
Favaloro, Emmanuel J.
Fareed, Jawed
Tafur, Alfonso
J.
Francese, Dominic P.
Batra, Jaya
Falanga, Anna and
Clerkin, Kevin J.
Uriel, Nir
Kirtane, Ajay
McLintock, Claire
and Hunt, Beverley J.
Spyropoulos, Alex C.
Barnes, Geoffrey D.
and Eikelboom, John W.
Weinberg, Ido
Schulman, Sam
Carrier,
Marc
Piazza, Gregory
Beckman, Joshua A.
Leon, Martin B. and
Stone, Gregg W.
Rosenkranz, Stephan
Goldhaber, Samuel Z. and
Parikh, Sahil A.
Monreal, Manuel
Krumholz, Harlan M. and
Konstantinides, Stavros V.
Weitz, Jeffrey I.
Lip, Gregory Y. H.
and Global COVID-19 Thrombosis Collabo
