Περίληψη:
Background. Strontium ranelate (StR) is an antiosteoporotic agent
previously utilized for the enhancement of fracture union. We
investigated the effects of StR on fracture healing using a rabbit
model. Methods. Forty adult female rabbits were included in the study
and were divided in 2 equal groups, according to StR treatment or
untreated controls. All animals were subjected to osteotomy of the ulna,
while the contralateral ulna remained intact and served as a control for
the biomechanical assessment of fracture healing. Animals in the study
group received 600 mg/kg/day of StR orally. All animals received
ordinary food. At 2 and 4 weeks, all animals were euthanatized and the
osteotomy sites were evaluated for healing through radiological,
biomechanical, and histopathological studies. Results. The treatment
group presented statistically significant higher callus diameter, total
callus area, percentage of fibrous tissue (p<0.001), vessels/mm(2),
number of total vessels, and lower osteoclast number/mm(2) (p<0.05) than
the control group at 2 weeks. Additionally, the treatment group
presented significantly higher percentages of new trabecular bone,
vessels/mm(2), osteoclast number/mm(2), and lower values for callus
diameter, as well as total callus area (p<0.05), than the control group
at 4 weeks. At 4 weeks, in the treatment group, force applied (p=0.003),
energy at failure (p=0.004), and load at failure (p=0.003) were all
significantly higher in the forearm specimens with the osteotomized
ulnae compared to those without. Radiological bone union was
demonstrated for animals receiving StR at 4 weeks compared with controls
(p=0.045). Conclusion. StR appears to enhance fracture healing but
further studies are warranted in order to better elucidate the
mechanisms and benefits of StR treatment.
Συγγραφείς:
Koukou, Ourania I.
Pappas, Lampros D.
Chloropoulou, Pelagia and
Kouroupi, Maria A.
Koukos, Konstantinos I.
Karpathiou, Georgia
and Galanos, Antonios A.
Drosos, Georgios I.
Magnisalis,
Evaggelos
Giatromanolaki, Alexandra N.
Verettas, Dionysios
Alexandros
