Περίληψη:
Objective. The aim was to examine hand function and performance in
activities of daily living (ADL) in patients with SLE vs healthy
controls, and any associations with demographic and disease-related
characteristics.
Methods. Hand function (grip strength, pinch strength and dexterity) and
ADL performance were evaluated in 240 patients with SLE and 122 age- and
biological sex-matched healthy controls. Grip strength, pinch strength
and dexterity were measured by Jamar dynamometer, pinch gauge and Purdue
pegboard test, respectively. Self-reported ADL performance was assessed
by disabilities of the arm, shoulder and hand (DASH) and HAQ. Regression
analysis was performed to assess the determinants of hand dysfunction.
Results. All hand function and ADL performance variables were
significantly impaired in the entire SLE cohort and the subgroup of
patients achieving lupus low disease activity state (LLDAS; n = 157)
compared with healthy subjects (P < 0.05). Joint pain, often
underestimated in SLE, was the major determinant of hand function and
ADL performance in multiple regression models. In addition, age was
correlated with grip strength and Purdue scores, gender with grip
strength, arthritis with DASH and HAQ, and use of immunosuppressives
with DASH, HAQ and grip strength. Likewise, in patients in LLDAS,
painful joints were correlated with DASH and HAQ, age with grip strength
and Purdue (P < 0.001), gender with grip strength, and
immunosuppressives with HAQ and grip strength.
Conclusion. Hand function and performance of daily activities are
significantly impaired in SLE, even in patients who achieve LLDAS,
suggesting the need for their evaluation and management in clinical
practice.
Συγγραφείς:
Keramiotou, Kyriaki
Anagnostou, Christos
Konstantonis, George
and Kataxaki, Evangelia
Sfikakis, Petros P.
Tektonidou, Maria G.
