Περίληψη:
Background: The surface of endothelial cells is covered with cell
adhesion molecules including E-selectin, intercellular adhesion
molecule-1 (ICAM-1), and vascular cell adhesion molecule 1 (VCAM-1) that
mediate the adhesion and extravasation of leukocytes and play a pivotal
role in inflammatory response. The aim of this study was to investigate
the role of expression of adhesion molecules in inflammatory bowel
disease (IBD) patients, irritable bowel syndrome (IBS) patients, and
normal colonic mucosa. Materials and Methods: IBS and IBD patients along
with normal colonic mucosa were recruited in the study. In all groups,
two biopsies were taken from each of the three anatomical sites
(terminal ileum, cecum, and rectum). Three monoclonal antibodies,
E-selectin mAb, VCAM-1 mAb, and ICAM-1 mAb, were applied for
immunohistochemical analysis. Results: In IBD patients, the expression
of intensity of E-selectin, VCAM-1, and ICAM-1 was found decreased, at
least in cecum and rectum, in comparison with IBS patients and controls
(P < 0.001, P < 0.005, and P < 0.007, respectively). Comparison of the
expression of intensity of the aforementioned molecules in IBS patients
and controls revealed significant augmentation at the cecum and rectum
of IBS patients. Conclusions: The expression of adhesion molecules
appeared lower in IBD patients compared to IBS patients and controls. In
addition, the expression of adhesion molecules appeared higher in IBS
compared to the control group. Therefore, it could be hypothesized that
the expression of adhesion molecules could be considered as an early
event in the process of proinflammatory IBS group and may be other
factors play a crucial role in the process of intestinal inflammation in
IBD patients.
Συγγραφείς:
Mitselou, Antigony
Grammeniatis, Vasileios
Varouktsi, Anna and
Papadatos, Stamatis S.
Klaroudas, Antonios
Katsanos,
Konstantinos
Galani, Vasiliki
