Περίληψη:
Background: Even though, Pseudomonas aeruginosa is a common cause of
hospital-acquired infections, treatment is challenging because of
decreasing rates of susceptibility to many broad-spectrum antibiotics.
Methods: Consumption data of eight broad spectrum antimicrobial agents
and resistance rates of P. aeruginosa were collected for 48 consecutive
months. Autoregressive integrated moving average (ARIMA) and transfer
functions models were used to develop relationships between antibiotic
use and resistance. Results: Positive correlations between P. aeruginosa
resistance and uses of ciprofloxacin (p < 0.001), meropenem (p < 0.001),
and cefepime (p = 0.005) were identified. Transfer function models
showed the quantified effect of each of these antibiotics on resistance.
Regarding levofloxacin, ceftazidime, piperacillin/tazobactam and
imipenem, no significant relationships were found. For ceftazidime and
levofloxacin, this was probably due to their low consumption, while for
imipenem the reason can possibly be ascribed to the already high
established P. aeruginosa resistance in the hospital. Conclusion: In the
hospital setting, the effect of antimicrobial agents' consumption on the
susceptibility epidemiology of P. aeruginosa differs significantly for
each one of them. In this study, the role of precedent use of meropenem,
cefepime and ciprofloxacin was quantified in the development of P.
aeruginosa resistance.
Συγγραφείς:
Kousovista, Rania
Athanasiou, Christos
Liaskonis, Konstantinos
and Ivopoulou, Olga
Karalis, Vangelis
